Microfluidics assisted biosensors for label-free optical monitoring of molecular interactions

被引：11
|
作者：
de Stefano, L. [1 ]
Orabona, E. [2 ]
Lamberti, A. [3 ]
Rea, I. [1 ]
Rendina, I. [1 ]
机构：
[1] IMM CNR, Inst Microelect & Microsyst, Unit Naples, I-80131 Naples, Italy
[2] Univ Naples Federico II, Dept Phys Sci, I-80126 Naples, Italy
[3] Univ Naples Federico II, Dept Biochem & Med Biotechnol, I-80131 Naples, Italy
来源：
SENSORS AND ACTUATORS B-CHEMICAL | 2013年 / 179卷
关键词：
Porous silicon; Microfluidics; Functionalization; Biosensors; POROUS-SILICON; HINDERED DIFFUSION; FABRICATION;
D O I：
10.1016/j.snb.2012.11.055
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
Porous silicon biosensors are by far used in optical monitoring of molecular interactions. These photonic devices could greatly benefit of integration with specific microfluidic circuits that allow small volume, and thus low consumption of reagents, fast time of incubation, and highly controlled reaction conditions. In this paper, we summarize the experience of our research group in fabrication and characterization of optical biochip, and also present new, original results on biosensing. In particular, a porous silicon based microarray of one-dimensional photonic crystals has been integrated with innovative microfluidic circuit for parallel feeding of chemical solutions. The device has been used for the label free optical monitoring of ssDNA-cDNA interaction. (C) 2012 Elsevier B.V. All rights reserved.
引用
收藏
页码：157 / 162
页数：6
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