Dehydroepiandrosterone sulfate (DHEAS) as an endocrine marker of aging in calorie restriction studies

被引:18
作者
Urbanski, Henryk F. [1 ,2 ,3 ,4 ]
Mattison, Julie A. [5 ]
Roth, George S. [6 ]
Ingram, Donald K. [7 ]
机构
[1] Oregon Hlth & Sci Univ, Div Neurosci, Oregon Natl Primate Res Ctr, Beaverton, OR 97006 USA
[2] Oregon Hlth & Sci Univ, Div Reprod & Dev Sci, Oregon Natl Primate Res Ctr, Beaverton, OR 97006 USA
[3] Oregon Hlth & Sci Univ, Dept Behav Neurosci, Portland, OR 97239 USA
[4] Oregon Hlth & Sci Univ, Dept Physiol & Pharmacol, Portland, OR 97239 USA
[5] NIA, Translat Gerontol Branch, NIH, Baltimore, MD 21224 USA
[6] GeroScience Inc, Pylesville, MD 21132 USA
[7] Louisiana State Univ Syst, Pennington Biomed Res Ctr, Nutr Neurosci & Aging Lab, Baton Rouge, LA 70808 USA
基金
美国国家卫生研究院;
关键词
Adrenal gland; Biomarker; Cortisol; DHEAS; Rhesus macaque; AGE-RELATED DECLINE; RHESUS-MONKEYS; IDENTIFYING BIOMARKERS; DIETARY RESTRICTION; OXIDATIVE STRESS; BLOOD-CHEMISTRY; LIFE-SPAN; HEMATOLOGY; LONGEVITY; MORTALITY;
D O I
10.1016/j.exger.2013.01.001
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
The adrenal steroid, dehydroepiandrosterone sulfate (DHEAS), is generally regarded as being a reliable endocrine marker of aging, because in humans and nonhuman primates its circulating concentrations are very high during young adulthood, and the concentrations then decline markedly during aging. Despite promising results from early studies, we were recently surprised to find that caloric restriction (CR) did little to prevent or delay the decline of DHEAS concentrations in old rhesus macaques. Here we summarize the use of circulating DHEAS concentrations as a biomarker of aging in CR studies and suggest reasons for its limited value. Although DHEAS can reliably predict aging in animals maintained on a standard diet, dietary manipulations may affect liver enzymes involved in the metabolism of steroid hormones. Consequently, in CR studies the reliability of using DHEAS as a biomarker of aging may be compromised. (C) 2013 Elsevier Inc. All rights reserved.
引用
收藏
页码:1136 / 1139
页数:4
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