IgG4 antibodies and cancer-associated inflammation Insights into a novel mechanism of immune escape

被引：31

作者：

Karagiannis, Panagiotis

Gilbert, Amy E.

Nestle, Frank O.

Karagiannis, Sophia N. ^{[1
]}

机构：

[1] St Johns Inst Dermatol, Div Genet & Mol Med, Cutaneous Med & Immunotherapy Unit, London, England

来源：

ONCOIMMUNOLOGY | 2013年 / 2卷 / 07期

基金：

英国工程与自然科学研究理事会;

关键词：

B cells; FcRI; IL-10; IgG4; VEGF; antibody effector functions; cancer inflammation; immune escape; melanoma; CELLS;

D O I：

10.4161/onci.24889

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The role of B cells and antibodies in cancer is insufficiently understood but is receiving increasing attention. We have recently identified IgG4 as an antibody subclass elicited by melanoma-associated interleukin-10-driven inflammation. In this setting, IgG4 exhibit inefficient immunostimulatory capacity and block the cytotoxic activities of other antibodies. These previously unappreciated mechanisms of immune escape may constitute promising targets for the development of novel anticancer immunotherapies.

引用

页数：3

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