N-Terminal Pro-B-Type Natriuretic Peptide Level Is Depressed in Patients With Significant Coronary Artery Disease Who Have High Body Mass Index

被引：6

作者：

Hong, Seo Na ^{[2
]}

Ahn, Youngkeun ^{[1
]}

Yoon, Nam Sik ^{[1
]}

Moon, Jae Youn ^{[1
]}

Kim, Kye Hun ^{[1
]}

Hong, Young Joon ^{[1
]}

Park, Hyung Wook ^{[1
]}

Kim, Ju Han ^{[1
]}

Jeong, Myung Ho ^{[1
]}

Cho, Jeong Gwan ^{[1
]}

Park, Jong Chun ^{[1
]}

Kang, Jung Chaee ^{[1
]}

机构：

[1] Chonnam Natl Univ, Chonnam Natl Univ Hosp, Ctr Heart,Dept Cardiovasc Med, Cardiovasc Res Inst,Program Gene & Cell Therapy, Kwangju 501757, South Korea

[2] Chonnam Natl Univ, Eun Hosp, Dept Internal Med, Kwangju 501757, South Korea

来源：

INTERNATIONAL HEART JOURNAL | 2008年 / 49卷 / 04期

关键词：

N-terminal pro-B-type natriuretic peptide; Coronary artery disease; Body mass index;

D O I：

10.1536/ihj.49.403

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

The aim of this study was to determine how body mass index (BMI) influences the N-terminal pro-B-type natriuretic peptide (NT-proBNP) level in patients with significant coronary artery disease (CAD). A total of 348 patients (6 1.5 +/- 9.2 years, male 67.5%) who had normal left ventricular systolic function were enrolled. All patients underwent percutaneous corollary intervention. We excluded patients with acute myocardial infarction, chronic heart failure, or renal dysfunction. Baseline NT-proBNP level was measured on admission. All underwent follow-up (F-U) coronary angiography (CAG) and the F-U NT-proBNP level was measured before F-U CAG. The patients were divided into two groups: an NT-proBNP < 100 pg/ mL group (group 1, n = 228) and an NT-proBNP > 200 pg/ml group (group 11, n = 120). BMI was significantly higher in group I than that in group 11 (26.5 +/- 2.2 versus 22.9 +/- 2.5 kg/m(2), P < 0.001). The level of NT-proBNP was negatively correlated with BMI and the levels of hemoglobin and apolipoprotein A1, and positively correlated with age, lipoprotein (a), and the Gensini score. In multivariate analysis, BMI was significantly related to a low NT-proBNP level in patients with CAD (odds ratio, 6.83; 95% confidence interval, 2.67-17.47; P < 0.001). The NT-proBNP level was not elevated in patients with a high BMI despite having significant CAD, and BMI was significantly related to a low NT-proBNP level in patients with significant CAD. (Int Heart J 2008; 49: 403-412)

引用

页码：403 / 412

页数：10

共 28 条

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