AlteredSOCS3DNA methylation within exon 2 is associated with increased mRNA expression in visceral adipose tissue in gestational diabetes

被引：5

作者：

Rancourt, Rebecca C. ^{[1
,2
,3
,4
]}

Ott, Raffael ^{[1
,2
,3
,4
]}

Schellong, Karen ^{[1
,2
,3
,4
]}

Ziska, Thomas ^{[1
,2
,3
,4
]}

Melchior, Kerstin ^{[1
,2
,3
,4
]}

Henrich, Wolfgang ^{[2
,3
,4
,5
]}

Plagemann, Andreas ^{[1
,2
,3
,4
]}

机构：

[1] Charite Univ Med Berlin, Clin Obstet, Div Expt Obstet, Berlin, Germany

[2] Free Univ Berlin, Berlin, Germany

[3] Humboldt Univ, Berlin, Germany

[4] Berlin Inst Hlth, Berlin, Germany

[5] Charite Univ Med Berlin, Clin Obstet, Berlin, Germany

来源：

EPIGENETICS | 2021年 / 16卷 / 05期

关键词：

Gestational diabetes mellitus; epigenetics; DNA methylation; SOCS3; adipose tissue; maternal blood; EPIGENOME-WIDE ASSOCIATION; SOCS3;

D O I：

10.1080/15592294.2020.1805695

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Overweight/obesity is the main risk factor for gestational diabetes mellitus (GDM). In our cohort of pregnant women with GDM, n = 19, and without, n = 22, we previously reported a significant increase inSOCS3mRNA expression (+62%) in visceral adipose tissue (VAT) according to GDM, without altered promoter DNA-methylation. Here, we examined methylation status of additionalSOCS3exon 2 regions in VAT and maternal blood. We found significantly altered methylation at specific CpG sites corresponding to aberrant mRNA expression levels ofSOCS3in VAT. We propose a potential regulatory element/region within exon 2; however, this region does not appear to be a good blood-marker representing VAT.

引用

页码：488 / 494

页数：7

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