Guanfacine monotherapy for ADHD/ASD comorbid with Tourette syndrome: a case report

被引：4

作者：

Okazaki, Kosuke ^{[1
]}

Yamamuro, Kazuhiko ^{[1
]}

Iida, Junzo ^{[2
]}

Kishimoto, Toshifumi ^{[1
]}

机构：

[1] Nara Med Univ, Sch Med, Dept Psychiat, 840 Shijo Cho, Kashihara, Nara 6348521, Japan

[2] Nara Med Univ, Sch Med, Fac Nursing, Kashihara, Nara, Japan

来源：

ANNALS OF GENERAL PSYCHIATRY | 2019年 / 18卷 / 1期

基金：

日本学术振兴会;

关键词：

Guanfacine; Atomoxetine; Methylphenidate; Attention deficit; hyperactivity disorder; Autism spectrum disorder; Tourette syndrome; ATTENTION-DEFICIT/HYPERACTIVITY DISORDER; DEFICIT HYPERACTIVITY DISORDER; RAT PREFRONTAL CORTEX; EXTENDED-RELEASE; EXTRACELLULAR DOPAMINE; LONG-TERM; CHILDREN; EFFICACY; NORADRENALINE; ADOLESCENTS;

D O I：

10.1186/s12991-019-0226-6

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

BackgroundPatients with attention deficit/hyperactivity disorder (ADHD) often experience comorbid conditions, such as autism spectrum disorder (ASD) and Tourette syndrome (TS). Although pharmacotherapies are effective for treating ADHD, they are likely to elicit a variety of adverse effects. It is, thus, important to select an effective and well-tolerated pharmacotherapeutic treatment for patients with ADHD/ASD comorbid with TS.Case presentationWe report the case of a 10-year-old boy with ADHD/ASD comorbid with TS who was treated with guanfacine (GUAN). He experienced several side effects of atomoxetine (ATX) and methylphenidate (MPH) before being treated with GUAN. In the presented case, symptoms of ADHD as well as tic symptoms were improved by treatment with GUAN.ConclusionGUAN might be effective and well tolerated in the treatment of patients with ADHD/ASD comorbid with TS who experience side effects of ATX and MPH.

引用

页数：5

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