A High Performance Liquid Chromatographic Method Using UV Detection for the Determination of Lisinopril

被引:0
|
作者
Vieriu, Madalina [1 ]
Bibire, Nela [1 ]
Peste, Gabriela [2 ]
Dorneanu, Vasile [1 ]
Potorac, Liliana [2 ]
机构
[1] Grigore T Popa Univ Med & Pharm, Fac Pharm, Dept Analyt Chem, Iasi 700115, Romania
[2] Antibiotice SA, Ctr Drug Evaluat, Iasi 707410, Romania
来源
REVISTA DE CHIMIE | 2013年 / 64卷 / 03期
关键词
lisinopril; HPLC analytical method; validation; CONVERTING ENZYME-INHIBITORS; HUMAN PLASMA; QUANTITATIVE-DETERMINATION; MASS-SPECTROMETRY; VALIDATION; HYDROCHLOROTHIAZIDE; DERIVATIVES; PYRIDAZINE;
D O I
暂无
中图分类号
O6 [化学];
学科分类号
0703 ;
摘要
A fast and simple HPLC method for the determination of lisinopril dissolved in pH 1.2 buffer was developed and validated. UV detection at 215 nm was used, on a HPLC Agilent 1200 system. Lisinopril was separated on a CS column using a mobile phase consisting of a mixture of 0.125% sodium hexanesulphonate solution prepared in phosphate buffer pH 2 and acetonitrile (72:28, v/v), at a flow rate of I mL.min(-1). The injected volume was 20 mu L. In these chromatographic conditions, the retention time of lisinopril was 1.9 minutes and the overall time of the analysis was 3 minutes. The proposed method was validated for a linear range of 0.6-60 mu g.mL(-1) with correlation coefficient of r = 0.9991. The precision and accuracy were within 1.3 % for inter- and intra-day HPLC runs. The overall recovery for lisinopril was 99%. This assay can be used for the therapeutic drug monitoring of lisinopril.
引用
收藏
页码:298 / 300
页数:3
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