Chemical modification of tryptophan residues in human plasminogen

被引：0

作者：

Zhao, CG ^{[1
]}

Liu, LY ^{[1
]}

Qiu, AD ^{[1
]}

Liu, SY ^{[1
]}

机构：

[1] HYG MINIST,INST BIOL PROD,CHANGCHUN 130062,PEOPLES R CHINA

来源：

CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE | 1997年 / 18卷 / 05期

关键词：

human plasminogen (HPg); tryptophan (Trp); chemical modification;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Tryptophan(Trp) residues in human plasminogen(HPg) was modified by N-bromossuccinimide (NBS), The results indicate that there are 19 tryptophan residues in HPg, Five tryptophan residues are located on the surface of the enzymogen, two of them are fast reactive residues, Among all the Trp residues, one is essential for the activity of the enzyme and may be located at the substrate binding site of the enzyme, The spectra of circular dichroism(CD) of HPg are changed after treatment with NBS.

引用

页码：744 / 747

页数：4

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