Invasive lesions containing filamentous forms produced by a Candida albicans mutant that is defective in filamentous growth in culture

被引：71
作者：
Riggle, FJ
Andrutis, KA
Chen, X
Tzipori, SR
Kumamoto, CA
机构：
[1] Tufts Univ, Sch Med, Dept Mol Biol & Microbiol, Boston, MA 02111 USA
[2] Tufts Univ, Sch Vet Med, Div Infect Dis, North Grafton, MA 01536 USA
来源：
INFECTION AND IMMUNITY | 1999年 / 67卷 / 07期
关键词：
D O I：
10.1128/IAI.67.7.3649-3652.1999
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
A Candida albicans efg1 cph1 double mutant is nonfilamentous under standard laboratory conditions and avirulent in mice. However, this mutant produced filaments in the tongues of immunosuppressed gnotobiotic piglets and when embedded in agar, demonstrating that an Efg1p- and Cph1p-independent pathway for promotion of filamentous growth exists.
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页码：3649 / 3652
页数：4
相关论文
共 12 条
[1]  
ANDRUTIS KA, UNPUB EXPT MUCOCUTAN
[2]   Control of filament formation in Candida albicans by the transcriptional repressor TUP1 [J].
Braun, BR ;
Johnson, AD .
SCIENCE, 1997, 277 (5322) :105-109
[3]  
BROWN DH, UNPUB FILAMENTOUS GR
[4]   Candida pathogenesis: Unravelling the threads of infection [J].
Corner, BE ;
Magee, PT .
CURRENT BIOLOGY, 1997, 7 (11) :R691-R694
[5]  
FONZI WA, 1993, GENETICS, V134, P717
[6]  
Gow Neil A. R., 1997, Current Topics in Medical Mycology, V8, P43
[7]   Biochemical and genetic characterization of Rbf1p, a putative transcription factor of Candida albicans [J].
Ishii, N ;
Yamamoto, M ;
Yoshihara, F ;
Arisawa, M ;
Aoki, Y .
MICROBIOLOGY-SGM, 1997, 143 :429-435
[8]   Transmission and serial propagation of Enterocytozoon bieneusi from humans and rhesus macaques in gnotobiotic piglets [J].
Kondova, I ;
Mansfield, K ;
Buckholt, MA ;
Stein, B ;
Widmer, G ;
Carville, A ;
Lackner, A ;
Tzipori, S .
INFECTION AND IMMUNITY, 1998, 66 (11) :5515-5519
[9]   SUPPRESSION OF HYPHAL FORMATION IN CANDIDA-ALBICANS BY MUTATION OF A STE12 HOMOLOG [J].
LIU, HP ;
KOHLER, J ;
FINK, GR .
SCIENCE, 1994, 266 (5191) :1723-1726
[10]   Nonfilamentous C-albicans mutants are avirulent [J].
Lo, HJ ;
Kohler, JR ;
DiDomenico, B ;
Loebenberg, D ;
Cacciapuoti, A ;
Fink, GR .
CELL, 1997, 90 (05) :939-949
12