Antagonism of miRNA-21 Sensitizes Human Gastric Cancer Cells to Paclitaxel

被引：34
|
作者：
Jin, Bo [1 ]
Liu, Yanping [2 ]
Wang, Haijiang [1 ]
机构：
[1] Xinjiang Med Univ, Xinjiang Tumor Hosp, Dept Gastroenteropathy Surg, Affiliated Hosp 3, Urumqi 830011, Xinjiang, Peoples R China
[2] Xinjiang Med Univ, Xinjiang Tumor Hosp, Dept Anesthesiol, Affiliated Hosp 3, Urumqi 830011, Xinjiang, Peoples R China
来源：
CELL BIOCHEMISTRY AND BIOPHYSICS | 2015年 / 72卷 / 01期
关键词：
miRNA-21; Gastric cancer; P-glycoprotein; BREAST-CANCER; PHASE-II; 2ND-LINE CHEMOTHERAPY; MULTIDRUG-RESISTANCE; MICRORNA EXPRESSION; P-GLYCOPROTEIN; INHIBITION; CHEMOSENSITIVITY; COMBINATION; INVOLVEMENT;
D O I：
10.1007/s12013-014-0450-2
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The development of drug resistance has largely limited the clinical outcome of anti-cancer treatment. Recent work has highlighted the involvement of non-coding RNAs, microRNAs (miRNAs), in cancer development. The present study aimed to investigate the role of miR-21 in the development of drug resistance to paclitaxel in gastric cancer cells. Our study found that the expression of miR-21 upregulated in the paclitaxel resistant cell line SGC7901/paclitaxel compared to its parental line SGC7901. Moreover, over-expression of miR-21 significantly decreased antiproliferative effects and apoptosis induced by paclitaxel, while knockdown of miR-21 dramatically increased antiproliferative effects and apoptosis induction by paclitaxel. Moreover, our results demonstrated that miR-21 may modulate the sensitivity to PTX, at least in part, by regulating the expression of P-glycoprotein.
引用
收藏
页码：275 / 282
页数：8
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