Schizophrenia comorbid with panic disorder: Evidence for distinct cognitive profiles

被引:15
作者
Rapp, Erica Kirsten [2 ]
White-Ajmani, Mandi Lynn [1 ]
Antonius, Daniel [1 ,3 ]
Goetz, Raymond Richard [1 ,4 ]
Harkavy-Friedman, Jill Martine [4 ]
Savitz, Adam Jonathan [5 ]
Malaspina, Dolores [1 ]
Kahn, Jeffrey Paul [5 ]
机构
[1] NYU, Dept Psychiat, Inst Social & Psychiat Initiat InSPIRES, Sch Med, New York, NY 10016 USA
[2] Mt Sinai Sch Med, Dept Psychiat, New York, NY USA
[3] SUNY Buffalo, Dept Psychiat, Sch Med & Biomed Sci, Buffalo, NY 14260 USA
[4] Columbia Univ, Dept Psychiat, New York State Psychiat Inst, New York, NY USA
[5] Weill Cornell Med Coll, Dept Psychiat, New York, NY USA
关键词
Schizophrenia; Schizoaffective disorder; Psychosis; Panic disorder; Anxiety disorder; Neuropsychological profile; Cognitive functioning; SCHIZOAFFECTIVE DISORDER; NEGATIVE SYMPTOMS; VIOLENT BEHAVIOR; ATTACKS; ANXIETY; PREVALENCE; INTELLIGENCE; INPATIENTS; FEATURES; SUBTYPES;
D O I
10.1016/j.psychres.2012.01.017
中图分类号
R749 [精神病学];
学科分类号
100205 ;
摘要
Patients with comorbid schizophrenia and panic symptoms share a distinct clinical presentation and biological characteristics, prompting some to propose panic psychosis as a separate subtype of schizophrenia. Less is known about these patients' neuropsychological profiles, knowledge of which may facilitate target-specific treatments and research into the etiopathophysiology for such cases. A total of 255 schizophrenia patients with panic disorder (n = 39), non-panic anxiety disorder (n = 51), or no anxiety disorder (n = 165) were assessed with the Wechsler Adult Intelligence Scale-Revised, the Wisconsin Card Sorting Test the Trail Making Test the Controlled Oral Word Association Test, the Animal Naming subtest of the Boston Diagnostic Aphasia Examination, and the Wechsler Memory Scale-Revised. Psychotic symptoms were assessed with the Positive and Negative Syndrome Scale. Patients with panic disorder demonstrated a higher verbal IQ and better problem solving, set switching, delayed recall, attention, and verbal fluency as compared to schizophrenia patients without comorbid anxiety. The schizophrenia-panic group reported a higher level of dysthymia on stable medication. Our findings suggest that patients with schizophrenia and comorbid panic disorder exhibit distinct cognitive functioning when compared to other schizophrenia patients. These data offer further support for a definable panic-psychosis subtype and suggest new etiological pathways for future research. (C) 2012 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:206 / 211
页数:6
相关论文
共 51 条
[1]   How Prevalent Are Anxiety Disorders in Schizophrenia? A Meta-Analysis and Critical Review on a Significant Association [J].
Achim, Amelie M. ;
Maziade, Michel ;
Raymond, Eric ;
Olivier, David ;
Merette, Chantal ;
Roy, Marc-Andre .
SCHIZOPHRENIA BULLETIN, 2011, 37 (04) :811-821
[2]   INTELLIGENCE IN SCHIZOPHRENIA - META-ANALYSIS OF THE RESEARCH [J].
AYLWARD, E ;
WALKER, E ;
BETTES, B .
SCHIZOPHRENIA BULLETIN, 1984, 10 (03) :430-459
[3]   Clinical features of panic attacks in schizophrenia [J].
Baylé, FJ ;
Krebs, MO ;
Epelbaum, C ;
Levy, D ;
Hardy, P .
EUROPEAN PSYCHIATRY, 2001, 16 (06) :349-353
[4]  
Benton A., 1989, MULTILINGUAL APHASIA
[5]   At issue: Hierarchical diagnosis in chronic schizophrenia: A clinical study of co-occurring syndromes [J].
Bermanzohn, PC ;
Porto, L ;
Arlow, PB ;
Pollack, S ;
Stronger, R ;
Siris, SG .
SCHIZOPHRENIA BULLETIN, 2000, 26 (03) :517-525
[6]  
Bermanzohn PC, 1999, AM J PSYCHIAT, V156, P1469
[7]   Psychiatric Comorbidities and Schizophrenia [J].
Buckley, Peter F. ;
Miller, Brian J. ;
Lehrer, Douglas S. ;
Castle, David J. .
SCHIZOPHRENIA BULLETIN, 2009, 35 (02) :383-402
[8]  
Cosoff SJ, 1998, AUST NZ J PSYCHIAT, V32, P67, DOI 10.1046/j.1440-1614.1998.00374.x
[9]   Obsessive-compulsive and panic symptoms in patients with first-admission psychosis [J].
Craig, T ;
Hwang, MY ;
Bromet, EJ .
AMERICAN JOURNAL OF PSYCHIATRY, 2002, 159 (04) :592-598
[10]   Comorbid conditions in schizophrenia [J].
Fenton, WS .
CURRENT OPINION IN PSYCHIATRY, 2001, 14 (01) :17-23