Synthesis of 2-substituted 4-quinazolone-5-carboxylic acids as inhibitors of DNA-gyrase

被引：0

作者：

Sui, ZH

Nguyen, VN

Fernandez, J

Barrett, JF

Ohemeng, KA

机构：

[1] R. W. Johnson Pharmaceutical Res. I., Drug Discovery, Raritan, NJ 08869

来源：

JOURNAL OF HETEROCYCLIC CHEMISTRY | 1997年 / 34卷 / 01期

关键词：

D O I：

10.1002/jhet.5570340124

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A series of 4-quinazolone-5-carboxylic acids were designed as bacterial DNA gyrase inhibitors. The syntheses of the target compounds were accomplished by reacting 3-aminophthalimide with aroyl chlorides followed by rearrangement of the resulting 3-acylaminophthalimides under basic conditions. The designed compounds showed moderate DNA gyrase inhibitory activity.

引用

页码：153 / 156

页数：4