Small Molecule Inhibitors of Signal Transducer and Activator of Transcription 3 (Stat3) Protein

被引:178
作者
Debnath, Bikash [1 ]
Xu, Shili [1 ]
Neamati, Nouri [1 ]
机构
[1] Univ So Calif, Sch Pharm, Dept Pharmacol & Pharmaceut Sci, Los Angeles, CA 90089 USA
关键词
GROWTH-SUPPRESSIVE ACTIVITY; HUMAN MULTIPLE-MYELOMA; TYROSINE-PHOSPHATASE SHP-1; EMBRYONIC STEM-CELLS; NF-KAPPA-B; CONSTITUTIVE ACTIVATION; LUNG-CANCER; IN-VITRO; SERINE PHOSPHORYLATION; MAINTAINS PLURIPOTENCY;
D O I
10.1021/jm300207s
中图分类号
R914 [药物化学];
学科分类号
100701 ;
摘要
[No abstract available]
引用
收藏
页码:6645 / 6668
页数:24
相关论文
共 168 条
[1]   Stat3 promotes metastatic progression of prostate cancer [J].
Abdulghani, Junaid ;
Gu, Lei ;
Dagvadorj, Ayush ;
Lutz, Jacqueline ;
Leiby, Benjamin ;
Bonuccelli, Gloria ;
Lisanti, Michael P. ;
Zellweger, Tobias ;
Alanen, Kalle ;
Mirtti, Tuomas ;
Visakorpi, Tapio ;
Bubendorf, Lukas ;
Nevalainen, Marja T. .
AMERICAN JOURNAL OF PATHOLOGY, 2008, 172 (06) :1717-1728
[2]   The Incidence, Correlation with Tumor-Infiltrating Inflammation, and Prognosis of Phosphorylated STAT3 Expression in Human Gliomas [J].
Abou-Ghazal, Mohamed ;
Yang, David S. ;
Qiao, Wei ;
Reina-Ortiz, Chantal ;
Wei, Jun ;
Kong, Ling-Yuan ;
Fuller, Gregory N. ;
Hiraoka, Nobuyoshi ;
Priebe, Waldemar ;
Sawaya, Raymond ;
Heimberger, Amy B. .
CLINICAL CANCER RESEARCH, 2008, 14 (24) :8228-8235
[3]   Silibinin inhibits constitutive activation of Stat3, and causes caspase activation and apoptotic death of human prostate carcinoma DU145 cells [J].
Agarwal, Chapla ;
Tyagi, Alpna ;
Kaur, Manjinder ;
Agarwal, Rajesh .
CARCINOGENESIS, 2007, 28 (07) :1463-1470
[4]   Guggulsterone, a farnesoid X receptor antagonist, inhibits constitutive and inducible STAT3 activation through induction of a protein tyrosine phosphatase SHP-1 (Publication with Expression of Concern. See vol. 78, pg. 5184, 2018) [J].
Ahn, Kwang Seok ;
Sethi, Gautam ;
Sung, Bokyung ;
Goel, Ajay ;
Ralhan, Ranju ;
Aggarwal, Bharat B. .
CANCER RESEARCH, 2008, 68 (11) :4406-4415
[5]   MOLECULAR-CLONING OF APRF, A NOVEL IFN-STIMULATED GENE FACTOR-3 P91-RELATED TRANSCRIPTION FACTOR INVOLVED IN THE GP130-MEDIATED SIGNALING PATHWAY [J].
AKIRA, S ;
NISHIO, Y ;
INOUE, M ;
WANG, XJ ;
WEI, S ;
MATSUSAKA, T ;
YOSHIDA, K ;
SUDO, T ;
NARUTO, M ;
KISHIMOTO, T .
CELL, 1994, 77 (01) :63-71
[6]  
[Anonymous], 2010, University of Central Florida Research Foundation, Inc., Patent No. [WO 2010033685, 2010033685]
[7]   Simultaneous tyrosine and serine phosphorylation of STAT3 transcription factor is involved in Rho A GTPase oncogenic transformation [J].
Aznar, S ;
Valerón, PF ;
del Rincon, SV ;
Pérez, LF ;
Perona, R ;
Lacal, JC .
MOLECULAR BIOLOGY OF THE CELL, 2001, 12 (10) :3282-3294
[8]   Blockade of STAT3 by antisense oligonucleotide in TNBS-induced murine colitis [J].
Bai, AiPing ;
Hu, PinJin ;
Chen, Jie ;
Song, Xin ;
Chen, Wei ;
Peng, WenXin ;
Zeng, ZhiRong ;
Gao, Xiang .
INTERNATIONAL JOURNAL OF COLORECTAL DISEASE, 2007, 22 (06) :625-635
[9]   The Small Molecule, LLL12, Inhibits STAT3 Phosphorylation and Induces Apoptosis in Medulloblastoma and Glioblastoma Cells [J].
Ball, Sarah ;
Li, Chenglong ;
Li, Pui-Kai ;
Lin, Jiayuh .
PLOS ONE, 2011, 6 (04)
[10]   STAT3 signalling is required for leptin regulation of energy balance but not reproduction [J].
Bates, SH ;
Stearns, WH ;
Dundon, TA ;
Schubert, M ;
Tso, AWK ;
Wang, YP ;
Banks, AS ;
Lavery, HJ ;
Haq, AK ;
Maratos-Flier, E ;
Neel, BG ;
Schwartz, MW ;
Myers, MG .
NATURE, 2003, 421 (6925) :856-859