OX40-mediated cosignal enhances the maturation of naive human CD4+ T cells into high IL-4-producing effectors

被引：19

作者：

Delespesse, G ^{[1
]}

Ohshima, Y ^{[1
]}

Yang, LP ^{[1
]}

Demeure, C ^{[1
]}

Sarfati, M ^{[1
]}

机构：

[1] Univ Montreal, Ctr Rech, CHUM, Lab Rech Allergie M4211 K, Montreal, PQ H2L 4M1, Canada

来源：

INTERNATIONAL ARCHIVES OF ALLERGY AND IMMUNOLOGY | 1999年 / 118卷 / 2-4期

关键词：

OX40; IL-4; Th2; cells; naive T cells;

D O I：

10.1159/000024143

中图分类号：

R392 [医学免疫学];

学科分类号：

100102 ;

摘要：

Our previous studies have indicated that naive human CD4+ T cells of neonatal or adult origin may be the initial source of IL-4 which is required for their development into Th2 effecters. In addition to minute amounts of IL-4, anti-CD3/B7.1-activated naive cells also release readily detectable levels of IL-13 and IFN-gamma. The production of IL-4 and IL-13 by naive T cells is differentially regulated by TGF-beta and IL-12. Shortly after activation, naive T cells express surface OX40, a TNF-R family member whose ligand (OX40L) is constitutively expressed on a subset of dendritic cells. Engagement of OX40 on activated naive T cells increases their expression of IL-4 and IL-13, suppresses that of IFN-gamma and promotes their development into Th2-like effecters.

引用

页码：384 / 386

页数：3

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