Photodynamic therapy with laser scanning mode of tumor irradiation

被引：20

作者：

Chepurna, Oksana ^{[1
]}

Shton, Irina ^{[2
]}

Kholin, Vladimir ^{[1
]}

Voytsehovich, Valerii ^{[3
]}

Popov, Viacheslav ^{[4
]}

Pavlov, Sergii ^{[5
]}

Gamaleia, Nikolai ^{[2
]}

Wojcik, Waldemar ^{[6
]}

Zhassandykyzy, Maral ^{[7
]}

机构：

[1] PSME Fotonika Plus, UA-18000 Cherkassy, Ukraine

[2] NAS Ukraine, Kavetsky Inst Expt Pathol Oncol & Radiobiol, UA-03022 Kiev 22, Ukraine

[3] NAS Ukraine, Inst Phys, UA-03028 Kiev, Ukraine

[4] State Sci Res Inst Phys Culture & Sports, UA-03680 Kiev, Ukraine

[5] Vinnitsia Natl Tech Univ, UA-21021 Vinnitsa, Ukraine

[6] Lublin Univ Technol, Inst Elect & Informat Technol, PL-20618 Lublin, Poland

[7] Kazakh Natl Res Tech Univ, Alma Ata 050013, Kazakhstan

来源：

OPTICAL FIBERS AND THEIR APPLICATIONS 2015 | 2015年 / 9816卷

关键词：

photodynamic therapy; photosensitizer; scanning laser irradiation; tumor;

D O I：

10.1117/12.2229030

中图分类号：

O43 [光学];

学科分类号：

070207 ; 0803 ;

摘要：

In this study we propose a new version of photodynamic therapy performed by laser scanning. The method consists in tumor treatment by a light beam of a small cross section which incrementally moves through the chosen area with a defined delay at each point and repetitively re-scans a zone starting from the initial position. Experimental evaluation of the method in vitro on murine tumor model showed that despite the dose, applied by scanning irradiation mode, was 400 times lower, the tumor inhibition rate conceded to attained with continuous irradiation mode by only 20%.

引用

页数：4

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