Copper(I) Iodide-Catalysed Aerobic Oxidative Synthesis of Imidazo[1,2-a]pyridines from 2-Aminopyridines and Methyl Ketones

被引：118

作者：

Mohan, Darapaneni Chandra ^{[1
]}

Donthiri, Ramachandra Reddy ^{[1
]}

Rao, Sadu Nageswara ^{[1
]}

Adimurthy, Subbarayappa ^{[1
]}

机构：

[1] Cent Salt & Marine Chem Res Inst, CSIR, Acad Sci & Innovat Res, Bhavnagar 364002, Gujarat, India

来源：

ADVANCED SYNTHESIS & CATALYSIS | 2013年 / 355卷 / 11-12期

关键词：

aerobic oxidation; CH activation; copper; imidazo[1; 2-a]pyridines; zolimidine synthesis; ONE-POT SYNTHESIS; MOLECULAR-OXYGEN; FACILE SYNTHESIS; ARYL; PALLADIUM; ACID; AIR; FUNCTIONALIZATION; IMIDAZOPYRIDINES; AMINOPYRIDINES;

D O I：

10.1002/adsc.201300456

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

We report here an operationally simple copper-catalysed synthesis of imidazo[1,2-a]pyridines through CH activation with oxidative linkage of two CN bonds under very mild conditions using molecular oxygen as a sole oxidant. The process allows the quick assembly of imidazo[1,2-a]pyridines including the antiulcer drug zolimidine from inexpensive and readily available 2-aminopyridines and methyl ketones with broad range of functional group tolerance.

引用

页码：2217 / 2221

页数：5

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