HIV-associated lymphoma in the era of combination antiretroviral therapy: shifting the immunological landscape

被引：23

作者：

Carroll, Virginia ^{[1
,2
]}

Garzino-Demo, Alfredo ^{[1
,2
,3
]}

机构：

[1] Univ Maryland, Sch Med, Inst Human Virol, Baltimore, MD 21201 USA

[2] Univ Maryland, Sch Med, Dept Microbiol & Immunol, Baltimore, MD 21201 USA

[3] Univ Padua, Dept Mol Med, I-35121 Padua, Italy

来源：

PATHOGENS AND DISEASE | 2015年 / 73卷 / 07期

关键词：

HIV-1; virus; lymphomagenesis; antiretroviral drugs; immune activation; chronic infection; DEPENDENT CELLULAR CYTOTOXICITY; AIDS-DEFINING CANCERS; NATURAL-KILLER-CELLS; BARR-VIRUS INFECTION; HODGKIN-LYMPHOMA; BONE-MARROW; T-CELLS; VIRAL REPLICATION; PROGENITOR CELLS; NK CELLS;

D O I：

10.1093/femspd/ftv044

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

HIV infection increases the risk of many types of cancer, including lymphoma. Combination antiretroviral therapy (cART) has reduced, but not eliminated, the risk of HIV-associated lymphoma. There has been a substantial shift in the subtypes of lymphoma observed in HIV-infected patients treated with cART. In this review, we will first outline these changes based on epidemiological studies and describe the impact of cART on lymphoma risk and mortality. Then, we will discuss some immunological factors that may contribute to the increased risk of lymphoma persisting after the administration of cART, including immunological non-response to therapy, chronic B-cell activation and dysfunction, T follicular helper cells, natural killer cells and altered lymphopoiesis. A better understanding of the pathophysiologic mechanisms of HIV-associated lymphoma under effective cART will inform future treatment strategies.

引用

页数：7

共 74 条

[1]

Basta D, 2015, ANGIOGENIC LYM UNPUB

[2] Characterization of Plasmablasts in the Blood of HIV-Infected Viremic Individuals: Evidence for Nonspecific Immune Activation [J].

Buckner, Clarisa M. ;

Moir, Susan ;

Ho, Jason ;

Wang, Wei ;

Posada, Jacqueline G. ;

Kardava, Lela ;

Funk, Emily K. ;

Nelson, Amy K. ;

Li, Yuxing ;

Chun, Tae-Wook ;

Fauci, Anthony S. .

JOURNAL OF VIROLOGY, 2013, 87 (10) :5800-5811

[3] HIV-1 Matrix Protein p17 Promotes Lymphangiogenesis and Activates the Endothelin-1/Endothelin B Receptor Axis [J].

Caccuri, Francesca ;

Rueckert, Christine ;

Giagulli, Cinzia ;

Schulze, Kai ;

Basta, Daniele ;

Zicari, Sonia ;

Marsico, Stefania ;

Cervi, Edoardo ;

Fiorentini, Simona ;

Slevin, Mark ;

Guzman, Carlos A. ;

Caruso, Arnaldo .

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY, 2014, 34 (04) :846-856

[4] HIV-1 matrix protein p17 promotes angiogenesis via chemokine receptors CXCR1 and CXCR2 [J].

Caccuri, Francesca ;

Giagulli, Cinzia ;

Bugatti, Antonella ;

Benetti, Anna ;

Alessandri, Giulio ;

Ribatti, Domenico ;

Marsico, Stefania ;

Apostoli, Paola ;

Slevin, Mark A. ;

Rusnati, Marco ;

Guzman, Carlos A. ;

Fiorentini, Simona ;

Caruso, Arnaldo .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2012, 109 (36) :14580-14585

[5] Genome wide DNA-profiling of HIV-related B-cell lymphomas [J].

Capello, Daniela ;

Scandurra, Marta ;

Poretti, Giulia ;

Rancoita, Paola M. V. ;

Mian, Michael ;

Gloghini, Annunziata ;

Deambrogi, Clara ;

Martini, Maurizio ;

Rossi, Davide ;

Greiner, Timothy C. ;

Chan, Wing C. ;

Ponzoni, Maurilio ;

Moreno, Santiago M. ;

Piris, Miguel A. ;

Canzonieri, Vincenzo ;

Spina, Michele ;

Tirelli, Umberto ;

Inghirami, Giorgio ;

Rinaldi, Andrea ;

Zucca, Emanuele ;

Favera, Riccardo D. ;

Cavalli, Franco ;

Larocca, Luigi Maria ;

Kwee, Ivo ;

Carbone, Antonino ;

Gaidano, Gianluca ;

Bertoni, Francesco .

BRITISH JOURNAL OF HAEMATOLOGY, 2010, 148 (02) :245-255

[6] AIDS-related non-Hodgkin's lymphomas: From pathology and molecular pathogenesis to treatment [J].

Carbone, A .

HUMAN PATHOLOGY, 2002, 33 (04) :392-404

[7] HIV-associated lymphomas and gamma-herpesviruses [J].

Carbone, Antonino ;

Cesarman, Ethel ;

Spina, Michele ;

Gloghini, Annunziata ;

Schulz, Thomas F. .

BLOOD, 2009, 113 (06) :1213-1224

[8] HIV-1 infects multipotent progenitor cells causing cell death and establishing latent cellular reservoirs [J].

Carter, Christoph C. ;

Onafuwa-Nuga, Adewunmi ;

McNamara, Lucy A. ;

Riddell, James ;

Bixby, Dale ;

Savona, Michael R. ;

Collins, Kathleen L. .

NATURE MEDICINE, 2010, 16 (04) :446-U127

[9] Epstein-Barr Virus Infection and Expression of B-cell Oncogenic Markers in HIV-Related Diffuse Large B-cell Lymphoma [J].

Chao, Chun ;

Silverberg, Michael J. ;

Martinez-Maza, Otoniel ;

Chi, Margaret ;

Abrams, Donald I. ;

Haque, Reina ;

Zha, Hongbin D. ;

McGuire, Michelle ;

Xu, Lanfang ;

Said, Jonathan .

CLINICAL CANCER RESEARCH, 2012, 18 (17) :4702-4712

[10] Survival of non-Hodgkin lymphoma patients with and without HIV infection in the era of combined antiretroviral therapy [J].

Chao, Chun ;

Xu, Lanfang ;

Abrams, Donald ;

Leyden, Wendy ;

Horberg, Michael ;

Towner, William ;

Klein, Daniel ;

Tang, Beth ;

Silverberg, Michael .

AIDS, 2010, 24 (11) :1765-1770

← 1 2 3 4 5 6 7 8 →