Addiction: failure of control over maladaptive incentive habits

被引:183
作者
Belin, David [1 ,2 ,3 ,4 ]
Belin-Rauscent, Aude [1 ,2 ,3 ,4 ]
Murray, Jennifer E. [3 ,4 ,5 ,6 ]
Everitt, Barry J. [3 ,4 ,5 ,6 ]
机构
[1] INSERM, LNEC, U1084, F-86000 Poitiers, France
[2] Univ Poitiers, INSERM AVENIR Team, F-86000 Poitiers, France
[3] Univ Poitiers, INSERM European Associated Lab Psychobiol Compuls, F-86000 Poitiers, France
[4] Univ Cambridge, Cambridge CB2 3EB, England
[5] Univ Cambridge, Behav & Clin Neurosci Inst, Cambridge CB2 3EB, England
[6] Univ Cambridge, Dept Psychol, Cambridge CB2 3EB, England
基金
英国惠康基金;
关键词
COCAINE-SEEKING BEHAVIOR; AMYGDALA CENTRAL NUCLEUS; VENTRAL TEGMENTAL AREA; BASOLATERAL AMYGDALA; DORSAL STRIATUM; DRUG-ADDICTION; DORSOLATERAL STRIATUM; 2ND-ORDER SCHEDULES; DOPAMINE-RECEPTORS; ALCOHOL SEEKING;
D O I
10.1016/j.conb.2013.01.025
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Drug addiction may be associated with a loss of executive control over maladaptive incentive habits. We hypothesize that these incentive habits result from a pathological coupling of drug-influenced motivational states and a rigid stimulus-response habit system by which drug-associated stimuli through automatic processes elicit and maintain drug seeking. Neurally, incentive habits may depend upon an interaction between the basolateral amygdala and nucleus accumbens core, together with the progressive development of a ventral-to-dorsolateral striatum functional coupling through the recruitment of striato-nigro-striatal dopamine-dependent loop circuitry. Recent evidence suggests that both ventral striatal and central nucleus pathways from the amygdala may be required for the recruitment of DLS-dependent control over habitual behavior.
引用
收藏
页码:564 / 572
页数:9
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