Regulation unmasked by activation

被引：1

作者：

Clark, Mike ^{[1
]}

Cooke, Anne ^{[1
]}

机构：

[1] Univ Cambridge, Dept Pathol, Cambridge CB2 1QP, England

来源：

NATURE IMMUNOLOGY | 2013年 / 14卷 / 07期

关键词：

D O I：

10.1038/ni.2646

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The glycoprotein CD52 is an important target for clinical antibodies, but its receptor and function have remained a mystery. However, it now seems that CD52 may be released in soluble form by a subpopulation of human T cells and may thereby exert an as-yet-unrecognized regulatory function via the inhibitory molecule Siglec-10.

引用

页码：696 / 697

页数：2

共 10 条

[1] T cell regulation mediated by interaction of soluble CD52 with the inhibitory receptor Siglec-10 [J].

Bandala-Sanchez, Esther ;

Zhang, Yuxia ;

Reinwald, Simone ;

Dromey, James A. ;

Lee, Bo-Han ;

Qian, Junyan ;

Boehmer, Ralph M. ;

Harrison, Leonard C. .

NATURE IMMUNOLOGY, 2013, 14 (07) :741-+

[2] Evolution of CD33-related siglecs: regulating host immune functions and escaping pathogen exploitation? [J].

Cao, Huan ;

Crocker, Paul R. .

IMMUNOLOGY, 2011, 132 (01) :18-26

[3] CD24 and Siglec-10 Selectively Repress Tissue Damage-Induced Immune Responses [J].

Chen, Guo-Yun ;

Tang, Jie ;

Zheng, Pan ;

Liu, Yang .

SCIENCE, 2009, 323 (5922) :1722-1725

[4] Alemtuzumab Therapy for Multiple Sclerosis [J].

Coles, Alasdair J. .

NEUROTHERAPEUTICS, 2013, 10 (01) :29-33

[5] Siglecs and their roles in the immune system [J].

Crocker, Paul R. ;

Paulson, James C. ;

Varki, Ajit .

NATURE REVIEWS IMMUNOLOGY, 2007, 7 (04) :255-266

[6] Human Siglec-10 can bind to vascular adhesion protein-1 and serves as its substrate [J].

Kivi, Elina ;

Elima, Kati ;

Aalto, Kristiina ;

Nymalm, Yvonne ;

Auvinen, Kaisa ;

Koivunen, Erkki ;

Otto, Diana M. ;

Crocker, Paul R. ;

Salminen, Tiina A. ;

Salmi, Marko ;

Jalkanen, Sirpa .

BLOOD, 2009, 114 (26) :5385-5392

[7] Cryptic sialic acid binding lectins on human blood leukocytes can be unmasked by sialidase treatment or cellular activation [J].

Razi, N ;

Varki, A .

GLYCOBIOLOGY, 1999, 9 (11) :1225-1234

[8] CROSS-LINKING OF THE CAMPATH-1 ANTIGEN (CD52) TRIGGERS ACTIVATION OF NORMAL HUMAN T-LYMPHOCYTES [J].

ROWAN, WC ;

HALE, G ;

TITE, JP ;

BRETT, SJ .

INTERNATIONAL IMMUNOLOGY, 1995, 7 (01) :69-77

[9] PRIMARY STRUCTURE OF CD52 [J].

TREUMANN, A ;

LIFELY, MR ;

SCHNEIDER, P ;

FERGUSON, MAJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1995, 270 (11) :6088-6099

[10] STRUCTURE OF THE CAMPATH-1 ANTIGEN, A GLYCOSYLPHOSPHATIDYLINOSITOL-ANCHORED GLYCOPROTEIN WHICH IS AN EXCEPTIONALLY GOOD TARGET FOR COMPLEMENT LYSIS [J].

XIA, MQ ;

HALE, G ;

LIFELY, MR ;

FERGUSON, MAJ ;

CAMPBELL, D ;

PACKMAN, L ;

WALDMANN, H .

BIOCHEMICAL JOURNAL, 1993, 293 :633-640

← 1 →