Pain vulnerability: a neurobiological perspective

被引：249

作者：

Denk, Franziska ^{[1
]}

McMahon, Stephen B. ^{[1
]}

Tracey, Irene ^{[2
,3
]}

机构：

[1] Kings Coll London, Wolfson Ctr Age Related Dis, London, England

[2] Univ Oxford, Oxford Ctr Funct Magnet Resonance Imaging Brain, Oxford, England

[3] Univ Oxford, Nuffield Dept Clin Neurosci, Nuffield Div Anaesthet, Oxford, England

来源：

NATURE NEUROSCIENCE | 2014年 / 17卷 / 02期

基金：

英国惠康基金;

关键词：

GENOME-WIDE ASSOCIATION; IRRITABLE-BOWEL-SYNDROME; CPG-BINDING PROTEIN-2; NEUROPATHIC PAIN; DNA METHYLATION; SPINAL-CORD; CENTRAL SENSITIZATION; FIBROMYALGIA PATIENTS; POSTSURGICAL PAIN; BRAIN-FUNCTION;

D O I：

10.1038/nn.3628

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

There are many known risk factors for chronic pain conditions, yet the biological underpinnings that link these factors to abnormal processing of painful signals are only just beginning to be explored. This Review will discuss the potential mechanisms that have been proposed to underlie vulnerability and resilience toward developing chronic pain. Particular focus will be given to genetic and epigenetic processes, priming effects on a cellular level, and alterations in brain networks concerned with reward, motivation/learning and descending modulatory control. Although research in this area is still in its infancy, a better understanding of how pain vulnerability emerges has the potential to help identify individuals at risk and may open up new therapeutic avenues.

引用

页码：192 / 200

页数：9

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