The role of MCM/P1 proteins in the licensing of DNA replication

被引：145
作者：
Chong, JPJ
Thommes, P
Blow, JJ
机构：
[1] ICRF Clare Hall Laboratories, Potters Bar, Herts, EN6 3LD, Blanche Lane
来源：
TRENDS IN BIOCHEMICAL SCIENCES | 1996年 / 21卷 / 03期
关键词：
D O I：
10.1016/S0968-0004(96)10013-X
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The DNA replication licensing system ensures that eukaryotic chromosomes replicate precisely once per cell cycle. A central component of the licensing system, RLF-M, has recently been shown to consist of a complex of Mcm/P1 proteins. This result allows us to integrate data about the MCM/P1 family obtained in different eukaryotes, ranging from yeast to man, into a general picture of the way that chromosome replication is controlled.
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收藏
页码：102 / 106
页数：5
相关论文
共 35 条
[1]   A CDC2-LIKE PROTEIN IS INVOLVED IN THE INITIATION OF DNA-REPLICATION IN XENOPUS EGG EXTRACTS [J].
BLOW, JJ ;
NURSE, P .
CELL, 1990, 62 (05) :855-862
[2]   A ROLE FOR THE NUCLEAR-ENVELOPE IN CONTROLLING DNA-REPLICATION WITHIN THE CELL-CYCLE [J].
BLOW, JJ ;
LASKEY, RA .
NATURE, 1988, 332 (6164) :546-548
[3]   PREVENTING RE-REPLICATION OF DNA IN A SINGLE-CELL CYCLE - EVIDENCE FOR A REPLICATION LICENSING FACTOR [J].
BLOW, JJ .
JOURNAL OF CELL BIOLOGY, 1993, 122 (05) :993-1002
[4]  
BURKHART R, 1995, EUR J BIOCHEM, V228, P431
[5]   CDC46/MCM5, A YEAST PROTEIN WHOSE SUBCELLULAR-LOCALIZATION IS CELL CYCLE-REGULATED, IS INVOLVED IN DNA-REPLICATION AT AUTONOMOUSLY REPLICATING SEQUENCES [J].
CHEN, YR ;
HENNESSY, KM ;
BOTSTEIN, D ;
TYE, BK .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (21) :10459-10463
[6]   PURIFICATION OF AN MCM-CONTAINING COMPLEXES A COMPONENT OF THE DNA-REPLICATION LICENSING SYSTEM [J].
CHONG, JPJ ;
MAHBUBANI, HM ;
KHOO, CY ;
BLOW, JJ .
NATURE, 1995, 375 (6530) :418-421
[7]   FISSION YEAST CDC21+ BELONGS TO A FAMILY OF PROTEINS INVOLVED IN AN EARLY STEP OF CHROMOSOME-REPLICATION [J].
COXON, A ;
MAUNDRELL, K ;
KEARSEY, SE .
NUCLEIC ACIDS RESEARCH, 1992, 20 (21) :5571-5577
[8]   CELL-CYCLE-REGULATED NUCLEAR IMPORT AND EXPORT OF CDC47, A PROTEIN ESSENTIAL FOR INITIATION OF DNA-REPLICATION IN BUDDING YEAST [J].
DALTON, S ;
WHITBREAD, L .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (07) :2514-2518
[9]  
FORSBURG SL, 1994, J CELL SCI, V107, P2779
[10]   THE PHENOTYPE OF THE MINICHROMOSOME MAINTENANCE MUTANT MCM3 IS CHARACTERISTIC OF MUTANTS DEFECTIVE IN DNA-REPLICATION [J].
GIBSON, SI ;
SUROSKY, RT ;
TYE, BK .
MOLECULAR AND CELLULAR BIOLOGY, 1990, 10 (11) :5707-5720
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