Effects of single and repeated stresses on the expression of mRNA for or α1-adrenoceptors in the rat hypothalamus and midbrain

被引：14
作者：
Miyahara, S
Komori, T
Fujiwara, R
Shizuya, K
Yamamoto, M
Ohmori, M
Okazaki, Y
机构：
[1] Mie Univ, Sch Med, Dept Psychiat, Tsu, Mie 5148507, Japan
[2] Kagawa Med Sch, Dept Pathol 1, Kita Ku, Kagawa 7610701, Japan
来源：
EUROPEAN JOURNAL OF PHARMACOLOGY | 1999年 / 379卷 / 01期
关键词：
alpha(1)-adrenoceptor; stress; alpha-adrenoceptor mRNA; hypothalamus; midbrain;
D O I：
10.1016/S0014-2999(99)00498-7
中图分类号：
R9 [药学];
学科分类号：
1007 ;
摘要：
We examined the effects of single or repeated stress on the expression of mRNA for alpha(1)-adrenoceptors in the rat hypothalamus and midbrain using the reverse transcriptase-polymerase chain reaction (RT-PCR). Single stress significantly increased the mRNA. level for alpha(1)-adrenoceptors in the midbrain, but had no effect on mRNA levels in the hypothalamus. Repeated stress significantly decreased mRNA levels for alpha(1)-adrenoceptors in both regions. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码：111 / 114
页数：4
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