Relapsing Wegener's granulomatosis: Successful treatment with cyclosporin-A

被引：17

作者：

Georganas, C ^{[1
]}

Ioakimidis, D ^{[1
]}

Iatrou, C ^{[1
]}

Vidalaki, B ^{[1
]}

Iliadou, K ^{[1
]}

Athanassiou, P ^{[1
]}

Kontomerkos, T ^{[1
]}

机构：

[1] DIST GEN HOSP ATHENS,DEPT RHEUMATOL,ATHENS,GREECE

来源：

CLINICAL RHEUMATOLOGY | 1996年 / 15卷 / 02期

关键词：

Wegener's granulomatosis; vasculitis; treatment; cyclophosphamide; cyclosporin-A; plasma exchange; immunoglobulin;

D O I：

10.1007/BF02230339

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

We describe the case of a 32-year-old splenectomised man with severe Wegener's granulomatosis which was refractory to conventional treatment with oral cyclophosphamide and prednisolone. Remission was temporarily induced only with plasma exchange or IV immunoglobulin. Because of frequent relapses of the disease and cyclophosphamide side effects, he was started on treatment with cyclosporin-ii and a long lasting remission was achieved.

引用

页码：189 / 192

页数：4

共 12 条

[1] TREATMENT OF WEGENER GRANULOMATOSIS WITH CYCLOSPORINE [J].

BORLEFFS, JCC ;

DERKSEN, RHWM ;

HENE, RJ .

ANNALS OF THE RHEUMATIC DISEASES, 1987, 46 (02) :175-175

[2] THE TREATMENT OF WEGENERS GRANULOMATOSIS WITH TRIMETHOPRIM SULFAMETHOXAZOLE - ILLUSION OR VISION [J].

DEREMEE, RA .

ARTHRITIS AND RHEUMATISM, 1988, 31 (08) :1068-1072

[3] WEGENERS GRANULOMATOSIS - PROSPECTIVE CLINICAL AND THERAPEUTIC EXPERIENCE WITH 85 PATIENTS FOR 21 YEARS [J].

FAUCI, AS ;

HAYNES, BF ;

KATZ, P ;

WOLFF, SM .

ANNALS OF INTERNAL MEDICINE, 1983, 98 (01) :76-85

[4] CYCLOSPORIN IN WEGENER GRANULOMATOSIS [J].

GREMMEL, F ;

DRUML, W ;

SCHMIDT, P ;

GRANINGER, W .

ANNALS OF INTERNAL MEDICINE, 1988, 108 (03) :491-491

[5]

Gross Wolfgang L., 1994, Current Opinion in Rheumatology, V6, P11, DOI 10.1097/00002281-199401000-00003

[6] WEGENER GRANULOMATOSIS - AN ANALYSIS OF 158 PATIENTS [J].

HOFFMAN, GS ;

KERR, GS ;

LEAVITT, RY ;

HALLAHAN, CW ;

LEBOVICS, RS ;

TRAVIS, WD ;

ROTTEM, M ;

FAUCI, AS .

ANNALS OF INTERNAL MEDICINE, 1992, 116 (06) :488-498

[7] TREATMENT OF WEGENERS GRANULOMATOSIS WITH INTERMITTENT HIGH-DOSE INTRAVENOUS CYCLOPHOSPHAMIDE [J].

HOFFMAN, GS ;

LEAVITT, RY ;

FLEISHER, TA ;

MINOR, JR ;

FAUCI, AS .

AMERICAN JOURNAL OF MEDICINE, 1990, 89 (04) :403-410

[8]

JENNETTE J C, 1992, Current Opinion in Rheumatology, V4, P9

[9] THE AMERICAN-COLLEGE-OF-RHEUMATOLOGY 1990 CRITERIA FOR THE CLASSIFICATION OF WEGENER GRANULOMATOSIS [J].

LEAVITT, RY ;

FAUCI, AS ;

BLOCH, DA ;

MICHEL, BA ;

HUNDER, GG ;

AREND, WP ;

CALABRESE, LH ;

FRIES, JF ;

LIE, JT ;

LIGHTFOOT, RW ;

MASI, AT ;

MCSHANE, DJ ;

MILLS, JA ;

STEVENS, MB ;

WALLACE, SL ;

ZVAIFLER, NJ .

ARTHRITIS AND RHEUMATISM, 1990, 33 (08) :1101-1107

[10] INFLUENCE OF DISEASE MANIFESTATION AND ANTINEUTROPHIL CYTOPLASMIC ANTIBODY TITER ON THE RESPONSE TO PULSE CYCLOPHOSPHAMIDE THERAPY IN PATIENTS WITH WEGENERS GRANULOMATOSIS [J].

REINHOLDKELLER, E ;

KEKOW, J ;

SCHNABEL, A ;

SCHMITT, WH ;

HELLER, M ;

BEIGEL, A ;

DUNCKER, G ;

GROSS, WL .

ARTHRITIS AND RHEUMATISM, 1994, 37 (06) :919-924

← 1 2 →