Design, synthesis and biological evaluation of novel hybrid compounds of imidazole scaffold-based 2-benzylbenzofuran as potent anticancer agents

被引：78

作者：

Wang, Xue-Quan ^{[1
]}

Liu, Lan-Xiang ^{[1
]}

Li, Yan ^{[2
]}

Sun, Cheng-Jun ^{[1
]}

Chen, Wen ^{[1
]}

Li, Liang ^{[1
]}

Zhang, Hong-Bin ^{[1
]}

Yang, Xiao-Dong ^{[1
]}

机构：

[1] Yunnan Univ, Sch Chem Sci & Technol, Minist Educ, Key Lab Med Chem Nat Resource, Kunming 650091, Peoples R China

[2] Chinese Acad Sci, Kunming Inst Bot, State Key Lab Phytochem & Plant Resources West Ch, Kunming 650204, Peoples R China

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2013年 / 62卷

基金：

中国国家自然科学基金;

关键词：

Hybrid compound; 2-Benzylbenzofuran; Imidazole; Cytotoxic activities; Structure-activity relationships; CYTOTOXIC ACTIVITIES; DERIVATIVES; ANALOGS; DISCOVERY; SALTS;

D O I：

10.1016/j.ejmech.2012.12.040

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

A series of novel hybrid compounds between 2-benzylbenzofuran and imidazole has been prepared and evaluated in vitro against a panel of human tumor cell lines. The results suggest that the existence of benzimidazole ring and substitution of the imidazolyl-3-positionwith a naphthylacyl or 4-methoxyphenacyl group were vital for modulating cytotoxic activity In particular, hybrid compounds 46 and 47 were found to be the most potent derivatives against 5 strains human tumor cell lines and more active than cisplatin (DDP), and exhibited cytotoxic activities selectively against breast carcinoma (MCF-7) and myeloid liver carcinoma (SMMC-7721), respectively. (C) 2013 Elsevier Masson SAS. All rights reserved.

引用

页码：111 / 121

页数：11

共 26 条

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