Design, synthesis, and application of novel chiral ONN ligands for asymmetric alkylation

被引：3

作者：

Bica, Katharina ^{[1
]}

Leder, Sonja ^{[1
]}

Mereiter, Kurt ^{[2
]}

Gaertner, Peter ^{[1
]}

机构：

[1] Vienna Univ Technol, Inst Appl Synthet Chem, A-1060 Vienna, Austria

[2] Vienna Univ Technol, Inst Chem Technol & Analyt, A-1060 Vienna, Austria

来源：

MONATSHEFTE FUR CHEMIE | 2013年 / 144卷 / 04期

关键词：

Chirality; Asymmetric synthesis; Ligands; Diethyl zinc; Organometallic compounds; Amino alcohols; CATALYTIC ENANTIOSELECTIVE ADDITION; AMINO-ALCOHOLS; TRIDENTATE LIGAND; ALDEHYDES; DIETHYLZINC; BENZALDEHYDE; DIALKYLZINCS; AMINOALCOHOLS; REDUCTION; COMPLEX;

D O I：

10.1007/s00706-012-0900-8

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Starting from easily available chiral pool amino alcohols, a set of novel chiral ONN ligands was synthesized and their catalytic potential was examined in asymmetric alkylation. Ligands with a secondary central NH group and N-methylated ONN ligands were successfully applied as catalysts in the addition of diethyl zinc to various aromatic aldehydes, yielding secondary alcohols in excellent yields of up to 99 % ee.

引用

页码：447 / 453

页数：7

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