A Novel Tirucallic Acid Derivative Induces Inhibition of the Akt/mTOR Pathway, G2 Cell Cycle Arrest, and Apoptosis in Chemoresistant Prostate Cancer Cells

被引:0
|
作者
El Gafaary, Menna [1 ]
Syrovets, Tatiana [1 ]
Buechele, Berthold [1 ]
Simmet, Thomas [1 ]
机构
[1] Inst Pharmacol Nat Prod & Clin Pharmacol, Ulm, Germany
关键词
D O I
暂无
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
021
引用
收藏
页码:S7 / S7
页数:1
相关论文
共 50 条
  • [1] Inhibition of Akt induces cell cycle arrest and triggers apoptosis in chemoresistant human prostate cancer cells
    Morad, S. A. F.
    Schmidt, M.
    Buechele, B.
    Pitterle, K.
    Lunov, O.
    Syrovets, T.
    Simmet, T.
    NAUNYN-SCHMIEDEBERGS ARCHIVES OF PHARMACOLOGY, 2009, 379 : 44 - 44
  • [2] Inhibition of the Akt pathway by tetracyclic triterpenoids induces cell cycle arrest and triggers apoptosis in human prostate cancer cells
    Estrada, A. C.
    Syrovets, T.
    Buechele, B.
    Schmidt, T.
    Simmet, T.
    PLANTA MEDICA, 2007, 73 (09) : 1001 - 1001
  • [3] Inhibition of AKT by novel tetracyclic triterpenoids induces cell cycle arrest and triggers apoptosis in human prostate cancer cells
    Estrada, A. C.
    Syrovets, T.
    Buechele, B.
    Schmidt, T.
    Schimana-Pfeifer, J.
    Simmet, T. H.
    EJC SUPPLEMENTS, 2007, 5 (04): : 61 - 61
  • [4] Inhibition of AKT/mTOR signaling pathway induces cell cycle arrest and apoptosis in acute myelogenous leukemia.
    Chen, WN
    Grammatikakis, I
    Li, J
    Leventaki, V
    Medeiros, LJ
    Rassidakis, GZ
    BLOOD, 2005, 106 (11) : 663A - 663A
  • [5] Oridonin induces G2/M cell cycle arrest and apoptosis via the PI3K/Akt signaling pathway in hormone-independent prostate cancer cells
    Lu, Jianlei
    Chen, Xiang
    Qu, Shuang
    Yao, Bing
    Xu, Yuexin
    Wu, Jiahui
    Jin, Yucui
    Ma, Changyan
    ONCOLOGY LETTERS, 2017, 13 (04) : 2838 - 2846
  • [6] Glaucocalyxin A induces G2/M cell cycle arrest and apoptosis through the PI3K/Akt pathway in human bladder cancer cells
    Lin, Wenfeng
    Xie, Jinlin
    Xu, Naijin
    Huang, Linglong
    Xu, Abai
    Li, Hulin
    Li, Chaoming
    Gao, Yubo
    Watanabe, Masami
    Liu, Chunxiao
    Huang, Peng
    INTERNATIONAL JOURNAL OF BIOLOGICAL SCIENCES, 2018, 14 (04): : 418 - 426
  • [7] HRT, Herbal Formula, Induces G2/M Cell Cycle Arrest and Apoptosis via Suppressing Akt Signaling Pathway in Human Colon Cancer Cells
    Yim, Nam-Hui
    Cho, Won-Kyung
    Lee, Ju Hye
    Jung, Young Pil
    Yang, Hye Jin
    Ma, Jin Yeul
    EVIDENCE-BASED COMPLEMENTARY AND ALTERNATIVE MEDICINE, 2012, 2012
  • [8] Deoxypodophyllotoxin induces G2/M cell cycle arrest and apoptosis in HeLa cells
    Shin, Soon Young
    Yong, Yeonjoong
    Kim, Chang Gun
    Lee, Young Han
    Lim, Yoongho
    CANCER LETTERS, 2010, 287 (02) : 231 - 239
  • [9] Vitexin induces G2/M-phase arrest and apoptosis via Akt/mTOR signaling pathway in human glioblastoma cells
    Zhang, Guangning
    Li, Dongyuan
    Chen, Hao
    Zhang, Junchen
    Jin, Xingyi
    MOLECULAR MEDICINE REPORTS, 2018, 17 (03) : 4599 - 4604
  • [10] Inhibition of AKT sensitizes chemoresistant ovarian cancer cells to cisplatin by abrogating S and G2/M arrest
    Zhang, Di
    Piao, Hai-Lan
    Li, Yan-Hong
    Qiu, Qing
    Li, Da-Jin
    Du, Mei-Rong
    Tsang, Benjamin K.
    EXPERIMENTAL AND MOLECULAR PATHOLOGY, 2016, 100 (03) : 506 - 513