Inhibitory effect on NO production of triterpenes from the fruiting bodies of Ganoderma lucidum

被引：50

作者：

Nguyen The Tung ^{[1
]}

To Dao Cuong ^{[1
]}

Tran Manh Hung ^{[1
]}

Lee, Jeong Hyung ^{[2
]}

Woo, Mi Hee ^{[1
]}

Choi, Jae Sue ^{[3
]}

Kim, Jaewang ^{[4
]}

Ryu, Sung Ho ^{[4
]}

Min, Byung Sun ^{[1
]}

机构：

[1] Catholic Univ Daegu, Coll Pharm, Gyeongbuk 712702, South Korea

[2] Kangwon Natl Univ, Coll Nat Sci, Kangweon 200701, South Korea

[3] Pukyong Natl Univ, Pusan 608737, South Korea

[4] Pohang Univ Sci & Technol, Div Mol & Life Sci, Pohang, South Korea

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2013年 / 23卷 / 05期

基金：

新加坡国家研究基金会;

关键词：

Ganoderma lucidum; Lanostane triterpenes; Inflammatory; RAW; 264.7; cells; NITRIC-OXIDE SYNTHASE; ADIPOCYTE DIFFERENTIATION; LANOSTANE TRITERPENES; FR KARST; ACID-F; CONSTITUENTS; EXTRACT; CELLS;

D O I：

10.1016/j.bmcl.2012.12.066

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Four new lanostane triterpenes, butyl lucidenate P (1), butyl lucidenate D-2 (2), butyl lucidenate E-2 (3) and butyl lucidenate Q (4) along with 11 known compounds (5-15) were isolated from the fruiting bodies of Ganoderma lucidum. Their chemical structures were established mainly by 1D and 2D NMR techniques and mass spectrometry. Their anti-inflammatory activity was evaluated against LPS-induced NO production in macrophage RAW 264.7 cells. Compounds 1, 3, 4, 9, 10 and 15 showed inhibitory potency with IC50 values of 7.4, 6.4, 4.3, 9.4, 9.2 and 4.5 mu M, respectively. Compounds 1, 3 and 15 dose-dependently reduced the LPS-induced iNOS expressions. Preincubation of cell with 1, 3 and 15 significantly suppressed LPS-induced expression of COX-2 protein. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：1428 / 1432

页数：5

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