Synthesis of α-helix mimetics with four side-chains

被引：33
|
作者：
Restorp, Per
Rebek, Julius, Jr. [1 ]
机构：
[1] Scripps Res Inst, Skaggs Inst Chem Biol, La Jolla, CA 92037 USA
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2008年 / 18卷 / 22期
关键词：
Alfa-helix mimetics; Protein-protein interaction; Heterocycles; Piperazines; N-Arylation;
D O I：
10.1016/j.bmcl.2008.06.074
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
The synthesis of a heterocyclic piperazine-based scaffold that mimics the i, i + 4, i + 8, i + 11 side-chain projections of an alpha-helix is described. The synthesis is designed to be modular to allow the targeting of a range of protein-protein interactions involving alpha-helices. (C) 2008 Elsevier Ltd. All rights reserved.
引用
收藏
页码：5909 / 5911
页数：3
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