Quantitative nucleic acids footprinting: Thermodynamic and kinetic approaches

被引：33
|
作者：
Petri, V [1 ]
Brenowitz, M [1 ]
机构：
[1] YESHIVA UNIV ALBERT EINSTEIN COLL MED, DEPT BIOCHEM, BRONX, NY 10461 USA
来源：
CURRENT OPINION IN BIOTECHNOLOGY | 1997年 / 8卷 / 01期
基金：
美国国家卫生研究院;
关键词：
D O I：
10.1016/S0958-1669(97)80155-3
中图分类号：
Q5 [生物化学];
学科分类号：
071010 ; 081704 ;
摘要：
Quantitative footprinting techniques allow a detailed analysis of the thermodynamic forces that characterize nucleic acid-ligand interactions and ligand-induced changes in nucleic acid structure by separately resolving the intrinsic and cooperative Gibbs free energy changes describing the reactions being investigated. A new implementation of the quantitative footprinting technique is the application of stopped-flow techniques to the study of kinetic reactions.
引用
收藏
页码：36 / 44
页数：9
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