Neutrophil extracellular traps A new link to cancer-associated thrombosis and potential implications for tumor progression

被引：150
作者：
Demers, Melanie
Wagner, Denisa D. [1 ]
机构：
[1] Boston Childrens Hosp, Program Cellular & Mol Med, Boston, MA USA
来源：
ONCOIMMUNOLOGY | 2013年 / 2卷 / 02期
关键词：
cancer; NETs; metastasis; neutrophils; thrombosis; tumor progression; INNATE IMMUNITY; LUNG METASTASIS; DNA TRAPS;
D O I：
10.4161/onci.22946
中图分类号：
R73 [肿瘤学];
学科分类号：
100214 ;
摘要：
Cancers prime neutrophils to release extracellular DNA traps through the systemic release of granulocyte colony-stimulating factor (G-CSF). We recently showed that these circulating neutrophil extracellular traps (NETs) promote the establishment of a pro-thrombotic state. The role of NETs in cancer biology and tumor progression may prove much more than an unfortunate side effect of cancer.
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