The Role of the Pentose Phosphate Pathway in Diabetes and Cancer

被引：290
作者：
Ge, Tongxin [1 ]
Yang, Jiawen [1 ]
Zhou, Shihui [1 ]
Wang, Yuchen [1 ]
Li, Yakui [1 ]
Tong, Xuemei [1 ]
机构：
[1] Shanghai Jiao Tong Univ, Shanghai Key Lab Tumor Microenvironm & Inflammat, Key Lab Cell Differentiat & Apoptosis, Dept Biochem & Mol Cell Biol,Minist Educ,Sch Med, Shanghai, Peoples R China
来源：
FRONTIERS IN ENDOCRINOLOGY | 2020年 / 11卷
基金：
国家重点研发计划; 中国国家自然科学基金;
关键词：
the pentose phosphate pathway; metabolism; obesity; diabetes; cancer; ACTIVATES 6-PHOSPHOGLUCONATE DEHYDROGENASE; ANABOLIC GLUCOSE-METABOLISM; ADIPOSE-TISSUE INFLAMMATION; HEPATIC INSULIN-RESISTANCE; CELL-CYCLE PROGRESSION; HIGH-DOSE THIAMINE; OXIDATIVE STRESS; HEPATOCELLULAR-CARCINOMA; PROTEOMIC ANALYSIS; SKELETAL-MUSCLE;
D O I：
10.3389/fendo.2020.00365
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
The pentose phosphate pathway (PPP) branches from glucose 6-phosphate (G6P), produces NADPH and ribose 5-phosphate (R5P), and shunts carbons back to the glycolytic or gluconeogenic pathway. The PPP has been demonstrated to be a major regulator for cellular reduction-oxidation (redox) homeostasis and biosynthesis. Enzymes in the PPP are reported to play important roles in many human diseases. In this review, we will discuss the role of the PPP in type 2 diabetes and cancer.
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页数：11
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