The role of palmitoylation in regulating Ras localization and function

被引：49

作者：

Eisenberg, Sharon ^{[1
]}

Laude, Alex J. ^{[2
]}

Beckett, Alison J. ^{[2
]}

Mageean, Craig J. ^{[2
]}

Aran, Veronica ^{[2
]}

Hernandez-Valladares, Maria ^{[2
]}

Henis, Yoav I. ^{[1
]}

Prior, Ian A. ^{[2
]}

机构：

[1] Tel Aviv Univ, George S Wise Fac Life Sci, Dept Neurobiol, IL-69978 Tel Aviv, Israel

[2] Univ Liverpool, Sch Biomed Sci, Div Phys, Liverpool L69 3BX, Merseyside, England

来源：

BIOCHEMICAL SOCIETY TRANSACTIONS | 2013年 / 41卷

基金：

英国惠康基金;

关键词：

compartmentalization; nanocluster; palmitoylation; Ras; signalling; trafficking; H-RAS; PLASMA-MEMBRANE; K-RAS; PROTEINS; TRAFFICKING; SIGNAL; CAAX; ASSOCIATION; SEGREGATION; ORIENTATION;

D O I：

10.1042/BST20120268

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Ras GTPases are important regulators of pathways controlling proliferation, differentiation and transformation. Three ubiquitously expressed almost identical Ras genes are not functionally redundant; this has been attributed to their distinctive trafficking and localization profiles. A palmitoylation cycle controls the correct compartmentalization of H-Ras and N-Ras. We review recent data that reveal how this cycle can be regulated by membrane organization to influence the spatiotemporal signalling of Ras.

引用

页码：79 / 83

页数：5

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