First Live Birth in Germany after Re-Transplantation of Cryopreserved Ovarian Tissue: Original Device for Initiation of Ice Formation

被引：23

作者：

Isachenko, Vladimir ^{[1
]}

Isachenko, Evgena ^{[1
]}

Keck, Gudrun ^{[2
]}

Dittrich, Ralf ^{[3
]}

Montag, Markus ^{[4
]}

van der Ven, Hans ^{[5
]}

Mallmann, Peter ^{[1
]}

Mueller, Andreas ^{[3
]}

Distler, Wolfgang ^{[2
]}

Beckmann, Matthias W. ^{[3
]}

Rahimi, Gohar ^{[1
]}

机构：

[1] Univ Frauenklin Cologne, Cologne, Germany

[2] Univ Frauenklin Dresden, Dresden, Germany

[3] Univ Frauenklin Erlangen, Erlangen, Germany

[4] Univ Frauenklin Heidelberg, Heidelberg, Germany

[5] Univ Frauenklin Bonn, Bonn, Germany

来源：

CLINICAL LABORATORY | 2012年 / 58卷 / 9-10期

关键词：

human; ovarian tissue; cooling; cryopreservation; ice-formation; live birth; FERTILITY PRESERVATION; AUTOTRANSPLANTATION; CANCER; VITRIFICATION; MORPHOLOGY; PREGNANCY; FOLLICLES; FAILURE; PATIENT; TUMORS;

D O I：

10.7754/Clin.Lab.2012.120224

中图分类号：

R446 [实验室诊断]; R-33 [实验医学、医学实验];

学科分类号：

1001 ;

摘要：

Background: The problem of post-cancer infertility is of significant concern. The cryopreservation of ovarian tissue before cancer therapy with retransplantation after convalescence is the key to solving this problem. Methods: Cryopreservation of ovarian tissue was performed in 2005 after surgical operation, post-operative low-temperature 22 hour transportation, and freezing using a special, original design block constructed for the initiation of ice formation (ice-seeding). We present the construction and function of this block. Results: In 2011, it was noted that a baby was born after thawing and re-transplantation of ovarian tissue. The technical and biological aspects of initiated crystals formation in the process of cryopreservation are emphasised and discussed. Conclusions: The first live birth in Germany after re-transplantation of cryopreserved ovarian tissue was noted. This cryopreservation was performed using the protocol described here. Block for auto-seeding of principally new construction recommended. (Clin. Lab. 2012;58:933-938. DOI: 10.7754/Clin.Lab.2012.120224)

引用

页码：933 / 938

页数：6

共 23 条

[21] First pregnancy and live birth in Turkey following frozen-thawed ovarian tissue transplantation in a patient with acute lymphoblastic leukemia who underwent cord blood transplantation
Murat Sonmezer
Sinan Ozkavukcu
Yavuz Emre Sukur
Duygu Kankaya
Onder Arslan
Journal of Assisted Reproduction and Genetics, 2020, 37 : 2033 - 2043
[22] Cryopreserved ovarian tissue autotransplantation in an acute myeloid leukaemia survivor following extensive minimal residual disease screening: first reported live birth in Europe
Soares, Michelle
Segers, Ingrid
De Brucker, Michael
Camboni, Alessandra
Hossay, Camille
Mateizel, Ileana
De Quick, Iebe
Van Moer, Ellen
Selleslag, Dominik
Hellebaut, Steven
Dolmans, Marie-Madeleine
De Vos, Michel
JOURNAL OF ASSISTED REPRODUCTION AND GENETICS, 2025,
[23] Live birth rate after female fertility preservation for cancer or haematopoietic stem cell transplantation: a systematic review and meta-analysis of the three main techniques; embryo, oocyte and ovarian tissue cryopreservation
Fraison, E.
Huberlant, S.
Labrune, E.
Cavalieri, M.
Montagut, M.
Brugnon, F.
Courbiere, B.
HUMAN REPRODUCTION, 2023, 38 (03) : 489 - 502

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