Non-peptide fibrinogen receptor antagonists.: 4.: The synthesis of [3H]L-756,568.

被引：0

作者：

Hamill, TG

Hutchinson, JH

Brashear, KM

Hartman, GD

机构：

[1] Merck Res Labs, Dept Pharmacol, W Point, PA 19486 USA

[2] Merck Res Labs, Dept Med Chem, W Point, PA 19486 USA

来源：

JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS | 1999年 / 42卷 / 06期

关键词：

fibrinogen receptor antagonist; L-756,568; catalytic tritiation;

D O I：

10.1002/(SICI)1099-1344(199906)42:6<605::AID-JLCR222>3.0.CO;2-L

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

The synthesis of [H-3]L-756,568, an orally active fibrinogen receptor antagonist, is described. Two synthetic pathways were developed using either bromoindoles 2a/2b or bromoaryl sulfonamide 11 as the precursor. Use of the bromoaryl sulfonamide precursor led to [H-3]L-756,568 with higher radiochemical purity, higher radiochemical yield, and slightly higher specific activity.

引用

页码：605 / 609

页数：5

共 50 条

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Journal of Labelled Compounds and Radiopharmaceuticals, 1999, 42 (06): : 605 - 609
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