PEG-400 promoted Pd(OAc)2/DABCO-catalyzed cross-coupling reactions in aqueous media

被引：123

作者：

Li, JH ^{[1
]}

Hu, XC ^{[1
]}

Liang, Y ^{[1
]}

Xie, YX ^{[1
]}

机构：

[1] Human Normal Univ, Coll Chem & Chem Engn, Changsha 410081, Peoples R China

来源：

TETRAHEDRON | 2006年 / 62卷 / 01期

基金：

中国国家自然科学基金;

关键词：

PEG-400; Pd(OAc)(2)/DABCO; cross-coupling reaction; aryl halide; arylboronic acids; organotin compounds;

D O I：

10.1016/j.tet.2005.09.138

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

PEG-400 [poly(ethylene glycol-400)] was found to improve the Pd(OAc)(2)/DABCO-catalyzed aqueous Suzuki-Miyaura and Stille cross-coupling reactions. In the presence of Pd(OAc)2, DABCO, and PEG-400, a variety of aryl halides were coupled with arylboronic acids or organotin compounds efficiently to afford the corresponding cross-coupled products in moderate to excellent yields. The turnover numbers was up to 900,000 for the Suzuki-Miyaura reaction and up to 9800 for the Stille reaction. The catalyst system was also effective for Heck and Sonogashira cross-coupling reactions to some extent. (c) 2005 Elsevier Ltd. All rights reserved.

引用

页码：31 / 38

页数：8

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