PEG-400 promoted Pd(OAc)2/DABCO-catalyzed cross-coupling reactions in aqueous media

被引：123
作者：
Li, JH [1 ]
Hu, XC [1 ]
Liang, Y [1 ]
Xie, YX [1 ]
机构：
[1] Human Normal Univ, Coll Chem & Chem Engn, Changsha 410081, Peoples R China
来源：
TETRAHEDRON | 2006年 / 62卷 / 01期
基金：
中国国家自然科学基金;
关键词：
PEG-400; Pd(OAc)(2)/DABCO; cross-coupling reaction; aryl halide; arylboronic acids; organotin compounds;
D O I：
10.1016/j.tet.2005.09.138
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
PEG-400 [poly(ethylene glycol-400)] was found to improve the Pd(OAc)(2)/DABCO-catalyzed aqueous Suzuki-Miyaura and Stille cross-coupling reactions. In the presence of Pd(OAc)2, DABCO, and PEG-400, a variety of aryl halides were coupled with arylboronic acids or organotin compounds efficiently to afford the corresponding cross-coupled products in moderate to excellent yields. The turnover numbers was up to 900,000 for the Suzuki-Miyaura reaction and up to 9800 for the Stille reaction. The catalyst system was also effective for Heck and Sonogashira cross-coupling reactions to some extent. (c) 2005 Elsevier Ltd. All rights reserved.
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收藏
页码：31 / 38
页数：8
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