The effects of cerebral white matter changes on cardiovascular responses to cognitive and physical activity in a stroke population

被引:5
作者
Williamson, J. B. [1 ,2 ]
Lewis, G. F. [3 ]
Nyenhuis, D. L. [4 ]
Stebbins, G. T. [5 ]
Murphy, C. [5 ]
Handelman, M. [3 ]
Harden, E. [3 ]
Heilman, K. M. [6 ]
Gorelick, P. B. [4 ]
Porges, S. W. [3 ]
机构
[1] Univ Florida, Coll Med, Dept Neurol, Gainesville, FL 32610 USA
[2] N Florida S Georgia Vet Affairs Med Ctr, Brain Rehabil Res Ctr, Gainesville, FL USA
[3] Univ Illinois, Dept Psychiat, Chicago, IL 60612 USA
[4] Univ Illinois, Dept Neurol & Rehabil, Chicago, IL USA
[5] Rush Univ, Med Ctr, Dept Neurol Sci, Chicago, IL 60612 USA
[6] N Florida S Georgia Vet Affairs Med Ctr, Ctr Geriatr Res Educ & Clin, Gainesville, FL USA
关键词
Laterality; Autonomic; Heart; Stroke; White matter; DTI; RESPIRATORY SINUS ARRHYTHMIA; BLOOD-PRESSURE REACTIVITY; EXECUTIVE DYSFUNCTION; FRONTAL-LOBE; CORTEX; IMPAIRMENT; ASYMMETRY; STRESS; ACTIVATION; HYPERINTENSITIES;
D O I
10.1111/j.1469-8986.2012.01467.x
中图分类号
B84 [心理学];
学科分类号
04 ; 0402 ;
摘要
Autonomic nervous system (ANS) control may be disrupted by cerebrovascular disease. We investigated the relationship between alterations in white matter integrity and regulation of the ANS in 23 participants who sustained a stroke within 5 years. These participants underwent diffusion tensor imaging, and fractional anisotropy values were calculated (DTI-FA) for each hemisphere and lobe. Cognitive and physical exertion tasks were performed while recording an electrocardiogram. Respiratory sinus arrhythmia (RSA) decreased more during a verbal fluency task with lower left hemisphere DTI-FA. Further, the physical stressor yielded decreases in RSA with lower frontal DTI-FA and higher temporal lobe DTI-FA, p < .05 (perhaps a release effect on the central autonomic network). Decrements in ANS regulation may have functional consequences that alter behavior, as well as potentially increasing the risk for further vascular disease.
引用
收藏
页码:1618 / 1628
页数:11
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