Needle core vs open biopsy for diagnosis of intermediate- and high-risk neuroblastoma in children

被引：51

作者：

Hassan, Saif F. ^{[1
]}

Mathur, Shawn ^{[1
]}

Magliaro, Thomas J. ^{[1
]}

Larimer, Emily L. ^{[1
]}

Ferrell, Lauren B. ^{[1
]}

Vasudevan, Sanjeev A. ^{[1
]}

Patterson, Danielle M. ^{[1
]}

Louis, Chrystal U. ^{[2
,3
]}

Russell, Heidi V. ^{[2
,3
]}

Nuchtern, Jed G. ^{[1
]}

Kim, Eugene S. ^{[1
]}

机构：

[1] Texas Childrens Hosp, Baylor Coll Med, Div Pediat Surg, Michael E DeBakey Dept Surg, Houston, TX 77030 USA

[2] Texas Childrens Hosp, Baylor Coll Med, Dept Pediat, Texas Childrens Canc Ctr,Sect Hematol Oncol, Houston, TX 77030 USA

[3] Texas Childrens Hosp, Baylor Coll Med, Dept Pediat, Hematol Ctr,Sect Hematol Oncol, Houston, TX 77030 USA

来源：

JOURNAL OF PEDIATRIC SURGERY | 2012年 / 47卷 / 06期

关键词：

Neuroblastoma; Needle core biopsy; Open biopsy; Risk stratifications; ASPIRATION-CYTOLOGY; TUMORS; MASSES; TRIAL;

D O I：

10.1016/j.jpedsurg.2012.03.040

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Background: Open biopsy has been the mainstay for definitive diagnosis of neuroblastoma in pediatric patients. However, needle core biopsy may represent a faster, less invasive, and safer alternative to open biopsy in children. The purpose of this study was to compare safety and efficacy between needle core and open biopsy in the diagnosis of patients with intermediate-and high-risk neuroblastoma at our institution. Methods: We retrospectively reviewed the medical records of children with intermediate-and high-risk neuroblastoma who underwent open or needle core biopsies from 2002 to 2010. Data collected included patient demographics, tumor size, sample adequacy for diagnosis and risk stratification (histology and cytogenetics), length of hospital stay, time to initiate chemotherapy after biopsy, need for repeat biopsy, and both intraoperative and postoperative complications. Mann-Whitney U and Fisher's exact tests were used for statistical analysis. Results: During the study period, 7 patients underwent needle core primary biopsies (5 intermediate-risk primary tumors and 2 high-risk primary tumors), and 4 patients underwent needle core biopsy for metastatic tumors, whereas 21 patients had open biopsies (10, intermediate risk; 11, high risk). Median age at biopsy and median tumor size were similar in both groups. There was no significant difference in adequacy of biopsy, need for repeat biopsy, time to initiate chemotherapy, length of stay, or minor complications. The rate of major complications differed significantly between the 2 groups with 0% after needle core biopsy vs 48% after open biopsy (P = .027). Conclusions: In children, needle core biopsy is comparable in efficacy with open biopsy in the diagnosis of intermediate-and high-risk neuroblastoma with significantly lower rates of major postoperative complications. These findings warrant a larger scale evaluation of diagnostic needle core biopsies in pediatric patients with solid tumor. (C) 2012 Elsevier Inc. All rights reserved.

引用

页码：1261 / 1266

页数：6

共 17 条

[1] Myeloablative megatherapy with autologous stem-cell rescue versus oral maintenance chemotherapy as consolidation treatment in patients with high-risk neuroblastoma: a randomised controlled trial [J].