Circadian Etiology of Type 2 Diabetes Mellitus

被引：165

作者：

Javeed, Naureen ^{[1
]}

Matveyenko, Aleksey V. ^{[1
,2
]}

机构：

[1] Mayo Clin, Dept Physiol & Biomed Engn, Rochester, MN 55905 USA

[2] Mayo Clin, Sch Med, Dept Med, Div Endocrinol Metab Diabet & Nutr, Rochester, MN 55905 USA

来源：

PHYSIOLOGY | 2018年 / 33卷 / 02期

基金：

美国国家卫生研究院;

关键词：

BETA-CELL FAILURE; MUSCLE INSULIN SENSITIVITY; DIET-INDUCED OBESITY; ARNT-LIKE PROTEIN-1; HIGH-FAT DIET; GLUCOSE-METABOLISM; SKELETAL-MUSCLE; SUPRACHIASMATIC NUCLEUS; DIURNAL-VARIATION; SHIFT-WORK;

D O I：

10.1152/physiol.00003.2018

中图分类号：

Q4 [生理学];

学科分类号：

071003 ;

摘要：

The epidemic of Type 2 diabetes mellitus necessitates development of novel therapeutic and preventative strategies to attenuate expansion of this debilitating disease. Evidence links the circadian system to various aspects of diabetes pathophysiology and treatment. The aim of this review will be to outline the rationale for therapeutic targeting of the circadian system in the treatment and prevention of Type 2 diabetes mellitus and consequent metabolic comorbidities.

引用

页码：138 / 150

页数：13

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