Assessment of preparation time with fully-liquid versus non-fully liquid paediatric hexavalent vaccines. A time and motion study

被引：35

作者：

De Coster, Ilse ^{[1
]}

Fournie, Xavier ^{[2
]}

Faure, Celine ^{[2
]}

Ziani, Eddy ^{[3
]}

Nicolas, Laurence ^{[3
]}

Soubeyrand, Benoit ^{[3
]}

Van Damme, Pierre ^{[1
]}

机构：

[1] Univ Antwerp, Vaccine & Infect Dis Inst, Ctr Evaluat Vaccinat, Fac Med & Hlth Sci, B-2610 Antwerp, Belgium

[2] Mapi, F-69003 Lyon, France

[3] Sanofi Pasteur MSD, F-69007 Lyon, France

来源：

VACCINE | 2015年 / 33卷 / 32期

关键词：

Time-motion study; Hexavalent vaccine; Childhood vaccination; Immunisation errors; IMMUNIZATION;

D O I：

10.1016/j.vaccine.2015.06.030

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Background and aims: Simplified vaccine preparation steps would save time and reduce potential immunisation errors. The aim of the study was to assess vaccine preparation time with fully-liquid hexavalent vaccine (DTaP-IPV-HB-PRP-T, Sanofi Pasteur MSD) versus non-fully liquid hexavalent vaccine that needs reconstitution (DTPa-HBV-IPV/Hib, GlaxoSmithKline Biologicals). Methods: Ninety-six Health Care Professionals (HCPs) participated in a randomised, cross-over, open-label, time and motion study in Belgium (2014). HCPs prepared each vaccine in a cross-over manner with a wash-out period of 3-5 min. An independent nurse assessed preparation time and immunisation errors by systematic review of the videos. HCPs satisfaction and preference were evaluated by a self-administered questionnaire. Results: Average preparation time was 36 s for the fully-liquid vaccine and 70.5 s for the non-fully liquid vaccine. The time saved using the fully-liquid vaccine was 34.5s (p <= 0.001). On 192 preparations, 57 immunisation errors occurred: 47 in the non-fully liquid vaccine group (including one missing reconstitution of Hib component), 10 in the fully-liquid vaccine group. 71.9% of HCPs were very or somewhat satisfied with the ease of handling of both vaccines; 66.7% and 67.7% were very or somewhat satisfied with speed of preparation in the fully-liquid vaccine and the non-fully liquid vaccine groups, respectively. Almost all HCPs (97.6%) stated they would prefer the use of the fully-liquid vaccine in their daily practice. Conclusions: Preparation of a fully-liquid hexavalent vaccine can be completed in half the time necessary to prepare a non-fully liquid vaccine. The simplicity of the fully-liquid hexavalent vaccine preparation helps optimise reduction of immunisation errors. (C) 2015 The Authors. Published by Elsevier Ltd. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).

引用

页码：3976 / 3982

页数：7

共 14 条

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