One-Month Transplacental Pharmacokinetics of Raltegravir in a Premature Newborn after Short-Course Treatment of the HIV-1-Infected Mother

被引：9

作者：

Clavel-Osorio, C. ^{[1
]}

Cazassus, F. ^{[2
]}

Stegmann, S. ^{[1
,3
]}

Huc-Anais, P.

Lecam, D. ^{[4
]}

Peytavin, G. ^{[5
]}

机构：

[1] LC Fleming Hosp, Infect Dis Unit, St Martin, St Kitts & Nevi

[2] LC Fleming Hosp, Dept Pediat, St Martin, St Kitts & Nevi

[3] Lab Lepers, St Martin, St Kitts & Nevi

[4] LC Fleming Hosp, Dept Gynecol, St Martin, St Kitts & Nevi

[5] Hop Xavier Bichat, Dept Pharmacol, Paris, France

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2013年 / 57卷 / 12期

关键词：

TOLERABILITY;

D O I：

10.1128/AAC.01349-13

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

We describe the pharmacokinetics of raltegravir of a preterm newborn after short-course treatment of the mother tested HIV + the day of delivery. At age 1 month, the circulating concentration of raltegravir in the newborn was 29 ng/ml (the IC95 of RAL against HIV-1 is 15 ng/ml). Raltegravir should therefore be considered a potential transplacental postexposure prophylaxis for HIV-1 and an alternative to the use of boosted lopinavir in this context.

引用

页码：6393 / +

页数：2

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