Ruthenium catalyzed desymmetrization of diazabicyclic olefins to access heteroaryl substituted cyclopentenes through C-H activation of phenylazoles

被引：11

作者：

Aparna, P. S. ^{[1
,2
]}

Prabha, B. ^{[1
]}

Prakash, Praveen ^{[1
]}

Jijy, E. ^{[1
]}

Varma, R. Luxmi ^{[1
,2
]}

Radhakrishnan, K. V. ^{[1
,2
]}

机构：

[1] CSIR, Natl Inst Interdisciplinary Sci & Technol, Organ Chem Sect, Chem Sci & Technol Div, Trivandrum 695019, Kerala, India

[2] Acad Sci & Innovat Res AcSIR, New Delhi 110001, India

来源：

TETRAHEDRON LETTERS | 2014年 / 55卷 / 04期

关键词：

Ruthenium; Cyclopentene; Bicyclic olefin; C-H activation; Pyrazole; MESO-BICYCLIC HYDRAZINES; DIRECT ORTHO ARYLATION; ONE-POT STRATEGY; BOND ACTIVATION; STEREOSELECTIVE-SYNTHESIS; GLYCOSIDASE INHIBITORS; OXIDATIVE ALKENYLATION; AZABICYCLIC OLEFINS; VERSATILE ACCESS; AROMATIC KETONES;

D O I：

10.1016/j.tetlet.2013.12.029

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

The first ruthenium catalyzed redox-neutral C-H activation strategy for the ring-opening of diazabicyclic olefins via C-H bond cleavage of phenyl azoles is reported. The developed method offers a novel route to functionalized cyclopentenes by employing less-expensive ruthenium catalyst and readily accessible biologically significant heteroarenes. The present protocol is a merger of the C-H activation of phenyl substituted heteroaromatics and subsequent beta-nitrogen elimination of diazabicyclic olefins. (C) 2013 Elsevier Ltd. All rights reserved.

引用

页码：865 / 868

页数：4

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