Ancient DNA Damage

被引：249

作者：

Dabney, Jesse ^{[1
]}

Meyer, Matthias ^{[1
]}

Paeaebo, Svante ^{[1
]}

机构：

[1] Max Planck Inst Evolutionare Anthropol, Dept Evolutionary Genet, D-04103 Leipzig, Germany

来源：

COLD SPRING HARBOR PERSPECTIVES IN BIOLOGY | 2013年 / 5卷 / 07期

关键词：

MISCODING LESIONS; SEQUENCES; PATTERNS; INSIGHTS; REVEALS;

D O I：

10.1101/cshperspect.a012567

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

Under favorable conditions DNA can survive for thousands of years in the remains of dead organisms. The DNA extracted from such remains is invariably degraded to a small average size by processes that at least partly involve depurination. It also contains large amounts of deaminated cytosine residues that are accumulated toward the ends of the molecules, as well as several other lesions that are less well characterized.

引用

页数：7

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