The associations between psychotic experiences and substance use and substance use disorders: findings from the World Health Organization World Mental Health surveys

被引：55

作者：

Degenhardt, Louisa ^{[1
]}

Saha, Sukanta ^{[2
,3
]}

Lim, Carmen C. W. ^{[2
,3
]}

Aguilar-Gaxiola, Sergio ^{[4
]}

Al-Hamzawi, Ali ^{[5
]}

Alonso, Jordi ^{[6
,7
,8
]}

Andrade, Laura H. ^{[9
]}

Bromet, Evelyn J.

Bruffaerts, Ronny ^{[10
]}

Caldas-de-Almeida, Jose Miguel ^{[11
,12
]}

de Girolamo, Giovanni ^{[13
]}

Florescu, Silvia ^{[14
]}

Gureje, Oye ^{[15
]}

Haro, Josep M. ^{[16
]}

Karam, Elie G. ^{[17
,18
,19
]}

Karam, Georges ^{[17
,18
,19
]}

Kovess-Masfety, Viviane ^{[20
,21
]}

Lee, Sing ^{[22
]}

Lepine, Jean-Pierre ^{[23
]}

Makanjuola, Victor ^{[15
]}

Medina-Mora, Maria E. ^{[24
]}

Mneimneh, Zeina ^{[25
]}

Navarro-Mateu, Fernando ^{[26
]}

Piazza, Marina ^{[27
,28
]}

Posada-Villa, Jose ^{[29
]}

Sampson, Nancy A. ^{[30
]}

Scott, Kate M. ^{[31
]}

Stagnaro, Juan Carlos ^{[32
]}

Ten Have, Margreet ^{[33
,34
]}

Kendler, Kenneth S.

Kessler, Ronald C. ^{[30
]}

McGrath, John J. ^{[2
,3
,35
]}

机构：

[1] Univ New South Wales, Natl Drug & Alcohol Res Ctr, Sydney, NSW, Australia

[2] Univ Queensland, Queensland Ctr Mental Hlth Res, St Lucia, Qld 4072, Australia

[3] Univ Queensland, Queensland Brain Inst, St Lucia, Qld 4072, Australia

[4] UC Davis Hlth Syst, Ctr Reducing Hlth Dispar, Sacramento, CA USA

[5] Al Qadisiya Univ, Coll Med, Diwaniya Governorate, Iraq

[6] IMIM Hosp Del Mar, Med Res Inst, Hlth Serv Res Unit, Barcelona, Spain

[7] Pompeu Fabra Univ UPF, Barcelona, Spain

[8] CIBER Epidemiol & Salud Publ CIBERESP, Barcelona, Spain

[9] Univ Sao Paulo, Fac Med, Hosp Clin, Inst Psiquiatria,Nucleo Epidemiol Psiquiatr LIM 2, Sao Paulo, Brazil

[10] Katholieke Univ Leuven UPC KUL, Univ Psychiatrisch Ctr, Campus Gasthuisberg, Leuven, Belgium

[11] Univ Nova Lisboa, Fac Ciencias Med, NOVA Med Sch, Lisbon Inst Global Mental Hlth, Lisbon, Portugal

[12] Univ Nova Lisboa, Fac Ciencias Med, NOVA Med Sch, Chron Dis Res Ctr CEDOC, Lisbon, Portugal

[13] IRCCS, St John God Clin Res Ctr, Unit Epidemiol & Evaluat Psychiat, Brescia, Italy

[14] Natl Sch Publ Hlth Management & Profess Dev Bucha, Bucharest, Romania

[15] Univ Coll Hosp, Dept Psychiat, Ibadan, Nigeria

[16] Univ Barcelona, CIBERSAM, Parc Sanitari St Joan Deu, Barcelona, Spain

[17] Balamand Univ, Fac Med, Dept Psychiat & Clin Psychol, Beirut, Lebanon

[18] Univ Med Ctr, St George Hosp, Dept Psychiat & Clin Psychol, Beirut, Lebanon

[19] IDRAAC, Beirut, Lebanon

[20] Univ Paris 05, EHESP Sch Publ Hlth, Lab Psychopathol & Proc Sante,EA 4057, EHESP Dpt MeTis Epidemiol & Biostat Decis Sante P, Paris, France

[21] Paris Descartes Univ, Dept Hlth Epidemiol & Biostat Decis Making Publ H, EA 4057, Paris, France

[22] Chinese Univ Hong Kong, Dept Psychiat, Hong Kong, Peoples R China

[23] Univ Paris Descartes Paris Diderot, Hop Lariboisiere Fernand Widal, Assistance Publ Hop Paris, Paris, France

[24] Natl Inst Psychiat Ramon Fuente, Mexico City, DF, Mexico

[25] Univ Michigan, Survey Res Ctr, Ann Arbor, MI 48109 USA

[26] CIBERESP Murcia, IMIB Arrixaca, Serv Murciano Salud, UDIF SM,Subdirecc Gen Planificac Innovac Cronicid, Murcia, Spain

[27] Univ Cayetano Heredia, Lima, Peru

[28] NIH, Lima, Peru

[29] Colegio Mayor Cundinamarca Univ, Fac Social Sci, Bogota, Colombia

[30] Harvard Med Sch, Dept Hlth Care Policy, Boston, MA USA

[31] Univ Otago, Dept Psychol Med, Dunedin, Otago, New Zealand

[32] Univ Buenos Aires, Fac Med, Dept Psiquiatria & Salud Mental, Buenos Aires, DF, Argentina

[33] Netherlands Inst Mental Hlth & Addict, Trimbos Inst, Utrecht, Netherlands

[34] Virginia Commonwealth Univ, Dept Psychiat, Richmond, VA 23284 USA

[35] Aarhus Univ, Aarhus BSS, Natl Ctr Register Based Res, Aarhus, Denmark

来源：

ADDICTION | 2018年 / 113卷 / 05期

基金：

巴西圣保罗研究基金会; 英国医学研究理事会;

关键词：

Alcohol; cannabis; mental disorder; nicotine; prescription drug; psychotic experiences; substance abuse disorder; substance dependence disorder; substance use; tobacco; 10-YEAR FOLLOW-UP; CANNABIS USE; RISK-FACTORS; SYMPTOMS; SCHIZOPHRENIA; POPULATION; ALCOHOL; ABUSE; COMORBIDITY; MARIJUANA;

D O I：

10.1111/add.14145

中图分类号：

R194 [卫生标准、卫生检查、医药管理];

学科分类号：

摘要：

Background and aims Prior research has found bidirectional associations between psychotic experiences (PEs) and selected substance use disorders. We aimed to extend this research by examining the bidirectional association between PEs and various types of substance use (SU) and substance use disorders (SUDs), and the influence of antecedent mental disorders on these associations. Design, setting, participants and measurements We used data from the World Health Organization World Mental Health surveys. A total of 30902 adult respondents across 18 countries were assessed for (a) six types of life-time PEs, (b) a range of types of SU and DSM-IV SUDs and (c) mental disorders using the Composite International Diagnostic Interview. Discrete-time survival analyses based on retrospective age-at-onset reports examined the bidirectional associations between PEs and SU/SUDs controlling for antecedent mental disorders. Findings After adjusting for demographics, comorbid SU/SUDs and antecedent mental disorders, those with prior alcohol use disorders [odds ratio (OR)=1.6, 95% confidence interval (CI)=1.2-2.0], extra-medical prescription drug use (OR=1.5, 95% CI=1.1-1.9), alcohol use (OR=1.4, 95% CI=1.1-1.7) and tobacco use (OR=1.3, 95% CI=1.0-1.8) had increased odds of subsequent first onset of PEs. In contrast, those with temporally prior PEs had increased odds of subsequent onset of tobacco use (OR=1.5, 95% CI=1.2-1.9), alcohol use (OR=1.3, 95% CI=1.1-1.6) or cannabis use (OR=1.3, 95% CI=1.0-1.5) as well as of all substance use disorders (ORs ranged between 1.4 and 1.5). There was a dose response relationship between both count and frequency of PEs and increased subsequent odds of selected SU/SUDs. Conclusions Associations between psychotic experiences (PEs) and substance use/substance use disorders (SU/SUDs) are often bidirectional, but not all types of SU/SUDs are associated with PEs. These findings suggest that it is important to be aware of the presence of PEs within those with SUDs or at risk of SUDs, given the plausibility that they may each impact upon the other.

引用

页码：924 / 934

页数：11

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