Hyperglycemia simultaneously induces initial caries development and enhances spontaneous occlusal surface wear in molar teeth related to parotid gland disorder in alloxan-induced diabetic rats

被引:5
作者
Nishimoto, Taiki [1 ]
Kodama, Yasushi [1 ]
Matsuura, Tetsuro [2 ]
Ozaki, Kiyokazu [2 ]
Taniguchi, Yoshihiko [1 ]
机构
[1] Hiroshima Int Univ, Fac Pharmaceut Sci, Lab Clinicopathol Therapeut, 5-1-1 Hirokoshingai, Kure, Hiroshima 7370112, Japan
[2] Setsunan Univ, Fac Pharmaceut Sci, Pathol Lab, 45-1 Nagaotoge Cho, Hirakata, Osaka 5730101, Japan
关键词
diabetes; hyperglycemia; dental caries; hyposalivation; occlusal wear; rat; SALIVARY FLOW-RATE; DENTAL-CARIES; TOOTH WEAR; PERIODONTAL-DISEASE; F344/N RATS; MELLITUS; XEROSTOMIA; SECRETION; ENAMEL;
D O I
10.1293/tox.2016-0054
中图分类号
R36 [病理学];
学科分类号
100104 ;
摘要
Diabetes and salivary gland dysfunction are major factors that induce dental caries in experimental animals, but there are no reports analyzing the association of dental caries and salivary glands in an animal model of diabetes mellitus (DM). To clarify the initial development of dental caries and preceding salivary gland disorder, we performed a histopathological analysis on teeth and salivary glands in diabetic Wistar rats 7 weeks after alloxan treatment (DM group) in comparison with nondiabetic rats (Non-DM group) and functional analysis on saliva secretion during the experimental period. Pilocarpine-induced salivary fluid secretion in diabetic rats gradually decreased with continuous hyperglycemia from immediately after alloxan treatment to the time of autopsy. Histopathologically, Oil Red O-positive lipid droplets accumulated in the acinar cells of the parotid gland. No tooth was stereoscopically defined as having dental caries in any of the rats in either group; however, the external appearance remarkably changed owing to occlusal wear in almost all molars in the DM group. The initial lesions of dental caries, appearing as micro-defects in dentin with bacterial colonization on the molar surface, were identified using histopathological analysis, and the incidence in the DM group was more than twice that in the Non-DM group. In conclusion, hyperglycemia simultaneously induces initial caries development and enhances spontaneous occlusal wear in molar teeth of Wistar rats 7 weeks after alloxan treatment. The parotid gland dysfunction caused by hyperglycemia may be mostly involved in the pathogenesis of occlusal wear as well as in dental caries in this diabetic model.
引用
收藏
页码:47 / 55
页数:9
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