The science and medicine of human immunology

被引：177

作者：

Pulendran, Bali ^{[1
,2
,3
,4
,5
]}

Davis, Mark M. ^{[1
,3
,5
,6
]}

机构：

[1] Stanford Univ, Inst Immun Transplantat & Infect, Stanford, CA 94305 USA

[2] Stanford Univ, Dept Pathol, Stanford, CA 94305 USA

[3] Stanford Univ, Dept Microbiol & Immunol, Stanford, CA 94305 USA

[4] Stanford Univ, Stanford ChEM H Chem Engn & Med Human Hlth, Stanford, CA 94305 USA

[5] Stanford Univ, Sch Med, Stanford, CA 94305 USA

[6] Stanford Univ, Howard Hughes Med Inst, Stanford, CA 94305 USA

来源：

SCIENCE | 2020年 / 369卷 / 6511期

基金：

比尔及梅琳达.盖茨基金会;

关键词：

YELLOW-FEVER VACCINE; HUMAN IMMUNE-SYSTEM; SEASONAL INFLUENZA; T-CELLS; RHEUMATOID-ARTHRITIS; ANTIBODY-RESPONSES; DENDRITIC CELLS; GUT MICROBIOTA; SENSOR GCN2; EXPRESSION;

D O I：

10.1126/science.aay4014

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Although the development of effective vaccines has saved countless lives from infectious diseases, the basic workings of the human immune system are complex and have required the development of animal models, such as inbred mice, to define mechanisms of immunity. More recently, new strategies and technologies have been developed to directly explore the human immune system with unprecedented precision. We discuss how these approaches are advancing our mechanistic understanding of human immunology and are facilitating the development of vaccines and therapeutics for infection, autoimmune diseases, and cancer.

引用

页码：1582 / +

页数：12

共 153 条

[31] Systems immunology: just getting started [J].

Davis, Mark M. ;

Tato, Cristina M. ;

Furman, David .

NATURE IMMUNOLOGY, 2017, 18 (07) :725-732

[32] Affinity of human IgG subclasses to mouse Fc gamma receptors [J].

Dekkers, Gillian ;

Bentlage, Arthur E. H. ;

Stegmann, Tamara C. ;

Howie, Heather L. ;

Lissenberg-Thunnissen, Suzanne ;

Zimring, James ;

Rispens, Theo ;

Vidarsson, Gestur .

MABS, 2017, 9 (05) :767-773

[33] TNF defined as a therapeutic target for rheumatoid arthritis and other autoimmune diseases [J].

Feldmann, M ;

Maini, RN .

NATURE MEDICINE, 2003, 9 (10) :1245-1250

[34] Role of cytokines in rheumatoid arthritis: an education in pathophysiology and therapeutics [J].

Feldmann, Marc ;

Maini, Ravinder N. .

IMMUNOLOGICAL REVIEWS, 2008, 223 :7-19

[35] Naturally occurring primary deficiencies of the immune system [J].

Fischer, A ;

CavazzanaCalvo, M ;

DesaintBasile, G ;

DeVillartay, JP ;

DiSanto, JP ;

Hivroz, C ;

RieuxLaucat, F ;

LeDeist, F .

ANNUAL REVIEW OF IMMUNOLOGY, 1997, 15 :93-124

[36] ANTIBODIES TO CACHECTIN TUMOR NECROSIS FACTOR REDUCE INTERLEUKIN-1-BETA AND INTERLEUKIN-6 APPEARANCE DURING LETHAL BACTEREMIA [J].

FONG, YM ;

TRACEY, KJ ;

MOLDAWER, LL ;

HESSE, DG ;

MANOGUE, KB ;

KENNEY, JS ;

LEE, AT ;

KUO, GC ;

ALLISON, AC ;

LOWRY, SF ;

CERAMI, A .

JOURNAL OF EXPERIMENTAL MEDICINE, 1989, 170 (05) :1627-1633

[37]

Food and Agriculture Organization of the United Nations International Fund for Agricultural Development UNICEF World Food Programme & World Health Organization, 2019, STAT FOOD SEC NUTR W

[38] Integrated systems approach defines the antiviral pathways conferring protection by the RV144 HIV vaccine [J].

Fourati, Slim ;

Ribeiro, Susan Pereira ;

Lopes, Filipa Blasco Tavares Pereira ;

Talla, Aarthi ;

Lefebvre, Francois ;

Cameron, Mark ;

Kaewkungwal, J. ;

Pitisuttithum, P. ;

Nitayaphan, S. ;

Rerks-Ngarm, S. ;

Kim, Jerome H. ;

Thomas, Rasmi ;

Gilbert, Peter B. ;

Tomaras, Georgia D. ;

Koup, Richard A. ;

Michael, Nelson L. ;

McElrath, M. Juliana ;

Gottardo, Raphael ;

Sekaly, Rafick-Pierre .

NATURE COMMUNICATIONS, 2019, 10 (1)

[39] Pre-vaccination inflammation and B-cell signalling predict age-related hyporesponse to hepatitis B vaccination [J].

Fourati, Slim ;

Cristescu, Razvan ;

Loboda, Andrey ;

Talla, Aarthi ;

Filali, Ali ;

Railkar, Radha ;

Schaeffer, Andrea K. ;

Favre, David ;

Gagnon, Dominic ;

Peretz, Yoav ;

Wang, I-Ming ;

Beals, Chan R. ;

Casimiro, Danilo R. ;

Carayannopoulos, Leonidas N. ;

Sekaly, Rafick-Pierre .

NATURE COMMUNICATIONS, 2016, 7

[40] Coexistence of potent HIV-1 broadly neutralizing antibodies and antibody-sensitive viruses in a viremic controller [J].

Freund, Natalia T. ;

Wang, Haoqing ;

Scharf, Louise ;

Nogueira, Lilian ;

Horwitz, Joshua A. ;

Bar-On, Yotam ;

Golijanin, Jovana ;

Sievers, Stuart A. ;

Sok, Devin ;

Cai, Hui ;

Lorenzi, Julio C. Cesar ;

Halper-Stromberg, Ariel ;

Toth, Ildiko ;

Piechocka-Trocha, Alicja ;

Gristick, Harry B. ;

van Gils, Marit J. ;

Sanders, Rogier W. ;

Wang, Lai-Xi ;

Seaman, Michael S. ;

Burton, Dennis R. ;

Gazumyan, Anna ;

Walker, Bruce D. ;

West, Anthony P., Jr. ;

Bjorkman, Pamela J. ;

Nussenzweig, Michel C. .

SCIENCE TRANSLATIONAL MEDICINE, 2017, 9 (373)

← 1 2 3 4 5 6 7 8 9 10 →