The science and medicine of human immunology

被引：177

作者：

Pulendran, Bali ^{[1
,2
,3
,4
,5
]}

Davis, Mark M. ^{[1
,3
,5
,6
]}

机构：

[1] Stanford Univ, Inst Immun Transplantat & Infect, Stanford, CA 94305 USA

[2] Stanford Univ, Dept Pathol, Stanford, CA 94305 USA

[3] Stanford Univ, Dept Microbiol & Immunol, Stanford, CA 94305 USA

[4] Stanford Univ, Stanford ChEM H Chem Engn & Med Human Hlth, Stanford, CA 94305 USA

[5] Stanford Univ, Sch Med, Stanford, CA 94305 USA

[6] Stanford Univ, Howard Hughes Med Inst, Stanford, CA 94305 USA

来源：

SCIENCE | 2020年 / 369卷 / 6511期

基金：

比尔及梅琳达.盖茨基金会;

关键词：

YELLOW-FEVER VACCINE; HUMAN IMMUNE-SYSTEM; SEASONAL INFLUENZA; T-CELLS; RHEUMATOID-ARTHRITIS; ANTIBODY-RESPONSES; DENDRITIC CELLS; GUT MICROBIOTA; SENSOR GCN2; EXPRESSION;

D O I：

10.1126/science.aay4014

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Although the development of effective vaccines has saved countless lives from infectious diseases, the basic workings of the human immune system are complex and have required the development of animal models, such as inbred mice, to define mechanisms of immunity. More recently, new strategies and technologies have been developed to directly explore the human immune system with unprecedented precision. We discuss how these approaches are advancing our mechanistic understanding of human immunology and are facilitating the development of vaccines and therapeutics for infection, autoimmune diseases, and cancer.

引用

页码：1582 / +

页数：12

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