Bioactive calcium phosphate silicate ceramic surface-modified PLGA for tendon-to-bone healing

被引：19
作者：
Guo, Jingshu [1 ,2 ]
Ning, Congqin [1 ]
Liu, Xuanyong [1 ]
机构：
[1] Chinese Acad Sci, Shanghai Inst Ceram, State Key Lab High Performance Ceram & Superfine, Shanghai 200050, Peoples R China
[2] Univ Chinese Acad Sci, Beijing 100049, Peoples R China
来源：
COLLOIDS AND SURFACES B-BIOINTERFACES | 2018年 / 164卷
基金：
美国国家科学基金会; 中国国家自然科学基金;
关键词：
Calcium phosphate silicate coating; PLGA; Surface modification; Tendon-to-bone healing; Electron beam evaporation; ELECTRON-BEAM EVAPORATION; IN-VITRO; CELL RESPONSE; THIN-FILM; DEPOSITION; COATINGS; REPAIR; VIVO;
D O I：
10.1016/j.colsurfb.2018.02.001
中图分类号：
Q6 [生物物理学];
学科分类号：
071011 ;
摘要：
Due to the dissimilar features between the tendon and bone, tendon to bone healing is the most challenging problems in sports medicine. In the present work, a novel bioactive calcium phosphate silicate ceramic (CPS) was coated on the surface of PLGA films using electron beam evaporation (EBE) technique to prepare a tailorable composite film with layered chemical composition similar to tendon-bone interface. The physicochemical behaviors of the CPS-PLGA composite films were characterized and the cytocompatibility were also investigated. It was found that the CPS-modified samples exhibited a significantly improved hydrophilicity and a more negative zeta potential. Cell culture results showed that the CPS-modified samples were beneficial to the attachment and proliferation of rBMSCs and NIH3T3 cells. CPS-modified samples also showed an improved osteogenic activity. The results suggested that CPS-modified PLGA films have great potentials for tendon-bone healing. (C) 2018 Elsevier B.V. All rights reserved.
引用
收藏
页码：388 / 395
页数：8
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