LncRNA FEZF1-AS1 Promotes TGF-β2-Mediated Proliferation and Migration in Human Lens Epithelial Cells SRA01/04

被引：11
作者：
Wang, Yong [1 ]
Chen, Lili [2 ]
Gu, Yonghui [3 ]
Wang, Ying [3 ]
Yuan, You [2 ]
Zhu, Qiujian [2 ]
Bi, Mingchao [4 ]
Gu, Shuyan [1 ]
机构：
[1] Cent South Univ, Aier Sch Ophthalmol, Changsha, Hunan, Peoples R China
[2] Soochow Univ, Lixiang Eye Hosp, Dept Ophthalmol, Suzhou, Jiangsu, Peoples R China
[3] Nanjing Med Univ, Affiliated Suzhou Hosp, Suzhou Municipal Hosp, Dept Ophthalmol, Suzhou, Jiangsu, Peoples R China
[4] Jilin Univ, Hosp 1, Dept Ophthalmol, Changchun, Jilin, Peoples R China
来源：
JOURNAL OF OPHTHALMOLOGY | 2019年 / 2019卷
关键词：
LONG NONCODING RNAS; MESENCHYMAL-TRANSITION; POOR-PROGNOSIS; GASTRIC-CANCER; PROGRESSION; ACTIVATION; EXPRESSION; FIBROSIS; ERK;
D O I：
10.1155/2019/4736203
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Posterior capsule opacification (PCO) is a common complication after cataract surgery attributed to the proliferation and migration of postoperative residual lens epithelial cells (LECs). The long noncoding RNA (lncRNA) FEZ family zinc finger 1 antisense RNA 1 (FEZF1-AS1) promotes the proliferation and migration of multiple types of cancer cells. Here, we discovered that FEZF1-AS1 is markedly upregulated in TGF-2-treated SRA01/04cells. In addition, the proliferation and migration of SRA01/04cells were enhanced following TGF-2 treatment. FEZF1-AS1 knockdown inhibited the TGF-2-induced proliferation and migration of SRA01/04cells. Accordingly, FEZF1-AS1 overexpression promoted the TGF-2-induced proliferation and migration of SRA01/04cells. Finally, FEZF1-AS1 upregulated TGF-2-induced SRA01/04cell proliferation and migration via boosting FEZF1 protein levels. Our findings indicate that the dysregulation of FEZF1-AS1 participates in the TGF-2-induced proliferation and migration of human lens epithelial cells (HLECs), which might be achieved, at least in part, through the induction of FEZF1 expression.
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页数：10
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