LncRNA FEZF1-AS1 Promotes TGF-β2-Mediated Proliferation and Migration in Human Lens Epithelial Cells SRA01/04

被引：10
|
作者：
Wang, Yong [1 ]
Chen, Lili [2 ]
Gu, Yonghui [3 ]
Wang, Ying [3 ]
Yuan, You [2 ]
Zhu, Qiujian [2 ]
Bi, Mingchao [4 ]
Gu, Shuyan [1 ]
机构：
[1] Cent South Univ, Aier Sch Ophthalmol, Changsha, Hunan, Peoples R China
[2] Soochow Univ, Lixiang Eye Hosp, Dept Ophthalmol, Suzhou, Jiangsu, Peoples R China
[3] Nanjing Med Univ, Affiliated Suzhou Hosp, Suzhou Municipal Hosp, Dept Ophthalmol, Suzhou, Jiangsu, Peoples R China
[4] Jilin Univ, Hosp 1, Dept Ophthalmol, Changchun, Jilin, Peoples R China
来源：
JOURNAL OF OPHTHALMOLOGY | 2019年 / 2019卷
关键词：
LONG NONCODING RNAS; MESENCHYMAL-TRANSITION; POOR-PROGNOSIS; GASTRIC-CANCER; PROGRESSION; ACTIVATION; EXPRESSION; FIBROSIS; ERK;
D O I：
10.1155/2019/4736203
中图分类号：
R77 [眼科学];
学科分类号：
100212 ;
摘要：
Posterior capsule opacification (PCO) is a common complication after cataract surgery attributed to the proliferation and migration of postoperative residual lens epithelial cells (LECs). The long noncoding RNA (lncRNA) FEZ family zinc finger 1 antisense RNA 1 (FEZF1-AS1) promotes the proliferation and migration of multiple types of cancer cells. Here, we discovered that FEZF1-AS1 is markedly upregulated in TGF-2-treated SRA01/04cells. In addition, the proliferation and migration of SRA01/04cells were enhanced following TGF-2 treatment. FEZF1-AS1 knockdown inhibited the TGF-2-induced proliferation and migration of SRA01/04cells. Accordingly, FEZF1-AS1 overexpression promoted the TGF-2-induced proliferation and migration of SRA01/04cells. Finally, FEZF1-AS1 upregulated TGF-2-induced SRA01/04cell proliferation and migration via boosting FEZF1 protein levels. Our findings indicate that the dysregulation of FEZF1-AS1 participates in the TGF-2-induced proliferation and migration of human lens epithelial cells (HLECs), which might be achieved, at least in part, through the induction of FEZF1 expression.
引用
收藏
页数：10
相关论文
共 50 条
  • [1] lncRNA FEZF1-AS1 Is Associated With Prognosis in Lung Adenocarcinoma and Promotes Cell Proliferation, Migration, and Invasion
    Liu, Zhenjun
    Zhao, Pei
    Han, Yuping
    Lu, Song
    ONCOLOGY RESEARCH, 2019, 27 (01) : 39 - 45
  • [2] lncRNA FEZF1-AS1 promotes migration, invasion and epithelial-mesenchymal transition of retinoblastoma cells by targeting miR-1236-3p
    Zhang, Guanghong
    Yang, Wei
    Li, Dujun
    Li, Xiaoyu
    Huang, Juan
    Huang, Rong
    Luo, Jihong
    MOLECULAR MEDICINE REPORTS, 2020, 22 (05) : 3635 - 3644
  • [3] The role of HIF-1α in the TGF-β2-mediated epithelial-to-mesenchymal transition of human lens epithelial cells
    Nahomi, Rooban B.
    Nagaraj, Ram H.
    JOURNAL OF CELLULAR BIOCHEMISTRY, 2018, 119 (08) : 6814 - 6827
  • [4] αB-crystallin is essential for the TGF-β2-mediated epithelial to mesenchymal transition of lens epithelial cells
    Nahomi, Rooban B.
    Pantcheva, Mina B.
    Nagaraj, Ram H.
    BIOCHEMICAL JOURNAL, 2016, 473 : 1455 - 1469
  • [5] Zinc Chloride Inhibits Human Lens Epithelial Cell Migration and Proliferation Involved in TGF-β1 and TNF-α Signaling Pathways in HLE B-3 Cells
    Du, Yuxiang
    Guo, Dadong
    Wu, Qiuxin
    Liu, Dongmei
    Bi, Hongsheng
    BIOLOGICAL TRACE ELEMENT RESEARCH, 2014, 159 (1-3) : 425 - 433
  • [6] Regulation of Na,K-ATPase β1-subunit in TGF-β2-mediated epithelial-to-mesenchymal transition in human retinal pigmented epithelial cells
    Mony, Sridevi
    Lee, Seung Joon
    Harper, Jeffrey F.
    Barwe, Sonali P.
    Langhans, Sigrid A.
    EXPERIMENTAL EYE RESEARCH, 2013, 115 : 113 - 122
  • [7] AGE-RAGE interaction in the TGFβ2-mediated epithelial to mesenchymal transition of human lens epithelial cells
    Raghavan, Cibin T.
    Nagaraj, Ram H.
    GLYCOCONJUGATE JOURNAL, 2016, 33 (04) : 631 - 643
  • [8] lncRNA TGFβ2-AS1 promotes ECM production via TGF-β2 in human trabecular meshwork cells
    Lv, Yingjuan
    Zhang, Zhanheng
    Xing, Xiaoli
    Liu, Aihua
    BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2020, 527 (04) : 881 - 888
  • [9] RAC1 overexpression promotes the proliferation, migration and epithelial-mesenchymal transition of lens epithelial cells
    Su, Jing
    Li, Hong
    INTERNATIONAL JOURNAL OF CLINICAL AND EXPERIMENTAL PATHOLOGY, 2015, 8 (09): : 10760 - 10767
  • [10] ERK1/2-mediated EGFR-signaling is required for TGFβ-induced lens epithelial-mesenchymal transition
    Shu, Daisy Y.
    Wojciechowski, Magdalena
    Lovicu, Frank J.
    EXPERIMENTAL EYE RESEARCH, 2019, 178 : 108 - 121
12345